Mann S, Millar Craig M W, Altman D G, Raftery E B, Hunyor S N
Clin Exp Hypertens A. 1985;7(2-3):187-94. doi: 10.3109/10641968509073538.
24h intra-arterial pressure monitoring was used to examine blood pressure variability in 5 normal volunteers, 137 subjects with suspected or established essential hypertension and 9 subjects with autonomic failure. Subjects with autonomic failure showed increased short-term blood pressure variability while active but reduced values at rest. Heart rate variability was low at all times. 24h recordings were reduced to hourly mean values and two indices of variability derived - day-night difference and average hourly change. For blood pressure, subjects with autonomic failure showed negative values of the former but high values of the latter; both indices of heart rate variability were low. In the remaining group, the relationship of these indices to constitutional factors, mean blood pressure and indices of physical activity during the study was explored. Day-night difference in systolic pressure was negatively correlated with mean pressure and average hourly change positively related to age. No other relationship was significant.
采用24小时动脉内血压监测来检查5名正常志愿者、137名疑似或确诊的原发性高血压患者以及9名自主神经功能衰竭患者的血压变异性。自主神经功能衰竭患者在活动时短期血压变异性增加，但静息时数值降低。心率变异性在所有时间均较低。将24小时记录简化为每小时平均值，并得出两个变异性指标——昼夜差值和每小时平均变化值。对于血压，自主神经功能衰竭患者的前者为负值，后者为高值；心率变异性的两个指标均较低。在其余组中，探讨了这些指标与体质因素、平均血压以及研究期间身体活动指标之间的关系。收缩压的昼夜差值与平均血压呈负相关，每小时平均变化值与年龄呈正相关。没有其他关系具有显著性。
