Mann S, Bellamy G R, Hunyor S N, Raftery E B, Ingall T, Bannister R
Clin Exp Pharmacol Physiol. 1984 Jul-Aug;11(4):347-50. doi: 10.1111/j.1440-1681.1984.tb00276.x.
Blood pressure variation over 24 h was studied in twelve subjects with suspected or established autonomic failure using ambulatory intra-arterial monitoring. Three subjects who had been previously diagnosed as having orthostatic hypotension due to autonomic failure were found to have normal circulatory reflexes. A generally consistent circadian variation of blood pressure was seen in the other nine subjects, pressure rising gradually from its lowest point early in the morning to a peak during the early part of the night; this pattern was also found during bed rest in four subjects. Supine hypertension (an hourly mean blood pressure of greater than 170/90 mmHg) not suspected from sphygmomanometric readings was observed in four subjects, generally during the night. Heart rate variability was reduced in six subjects while short-term blood pressure variability was markedly increased.
使用动态动脉内监测法对12名疑似或确诊为自主神经功能衰竭的受试者进行了24小时血压变化研究。3名先前被诊断因自主神经功能衰竭而患有体位性低血压的受试者被发现循环反射正常。在其他9名受试者中观察到血压呈现大致一致的昼夜变化，血压从清晨的最低点逐渐上升至夜间早期达到峰值；4名受试者在卧床休息时也发现了这种模式。4名受试者通常在夜间出现了从血压计读数未怀疑到的仰卧位高血压（每小时平均血压大于170/90 mmHg）。6名受试者的心率变异性降低，而短期血压变异性显著增加。
