Balázs M, Halmos T
Exp Pathol. 1985;27(3):153-62. doi: 10.1016/s0232-1513(85)80037-2.
Electron microscopic studies of 13 cases of liver fibrosis associated with longstanding diabetes mellitus are presented. Comparing the centrilobular and periportal areas of the lobules there appeared to be a difference in the amounts of glycogen, fat, collagen and the character of mesenchymal cells. Centrilobularly, collagenization of sinusoids and pericellular accumulation of fibres appeared with the destruction of hepatic cells. In the periportal regions there was an accumulation of Kupffer's cells with active phagocytosis and centrally of Ito's cells and fibroblasts. The presented alterations were similar to the central pericellular fibrosis described in connection with morbid obesity. Despite the large number of available data on liver fibrosis there is still no satisfactory explanation for the pathomechanism of centrilobularly developing fibrosis.
本文呈现了13例与长期糖尿病相关的肝纤维化病例的电子显微镜研究结果。比较小叶的中央小叶区和汇管区，发现糖原、脂肪、胶原蛋白的含量以及间充质细胞的特征存在差异。在中央小叶区，随着肝细胞的破坏，出现了肝血窦的胶原化和纤维在细胞周围的堆积。在汇管区，库普弗细胞积聚并具有活跃的吞噬作用，中央静脉周围有伊托细胞和成纤维细胞。所呈现的这些改变类似于与病态肥胖相关的中央细胞周围纤维化。尽管有大量关于肝纤维化的可用数据，但对于中央小叶区发生纤维化的发病机制仍没有令人满意的解释。
