Harvey C D, Sherwin A L, Van Der Kleijn E
Can J Neurol Sci. 1977 May;4(2):89-92.
Gray and white matter were obtained during neurosurgical therapy of focal epilepsy from 17 patients. In 10 patients, receiving only phenobarbital, the drug was uniformly distributed between gray and white matter. Phenytoin concentrations averaged 1.4-fold greater in white matter than in gray matter when expressed per gram wet weight of tissue. The gray matter/plasma ratio of phenytoin was approximately 2-fold greater than that of phenobarbital. Carbamazepine levels were also slightly greater in white matter. The data revealed wide differences between drugs in the relative concentrations in gray and white matter, which must be taken into account in any quantitative studies of anticonvulsant drug levels in the brain.
在对17例局灶性癫痫患者进行神经外科治疗期间获取了灰质和白质样本。10例仅接受苯巴比妥治疗的患者中，该药物在灰质和白质中分布均匀。以每克组织湿重计算，苯妥英在白质中的浓度平均比灰质高1.4倍。苯妥英的灰质/血浆比值比苯巴比妥大约高2倍。卡马西平在白质中的水平也略高。数据显示不同药物在灰质和白质中的相对浓度存在很大差异，在对脑内抗惊厥药物水平进行任何定量研究时都必须考虑到这一点。
