PET/CT中基于多价成纤维细胞活化蛋白抑制剂的放射性药物：从癌症诊断到诊疗一体化。
Multivalent FAPI-based radiopharmaceuticals in PET/CT: from cancer diagnostics to theranostics.
作者信息
Zhao Taoqian, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, United States.
出版信息
Am J Nucl Med Mol Imaging. 2025 Apr 15;15(2):82-86. doi: 10.62347/TUZI7617. eCollection 2025.
Abstract
Radiopharmaceuticals targeting fibroblast activation protein (FAP) have rapidly emerged as innovative agents for cancer imaging and therapy. By selectively binding to cancer-associated fibroblasts (CAFs), radiolabeled FAP inhibitors (FAPIs) enable high-contrast PET/CT imaging across diverse tumor types. This article highlights recent advances in FAPI PET/CT imaging, with particular focus on the influence of multivalency effect in radiotracer development.
摘要
靶向成纤维细胞活化蛋白（FAP）的放射性药物已迅速成为癌症成像和治疗的创新药物。通过选择性地与癌症相关成纤维细胞（CAF）结合，放射性标记的FAP抑制剂（FAPI）能够对多种肿瘤类型进行高对比度PET/CT成像。本文重点介绍了FAPI PET/CT成像的最新进展，特别关注多价效应在放射性示踪剂开发中的影响。
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