Milani Ilaria, Guarisco Gloria, Chinucci Marianna, Gaita Chiara, Leonetti Frida, Capoccia Danila
Faculty of Pharmacy and Medicine, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latin 04100, Italy.
JCEM Case Rep. 2025 May 21;3(7):luaf109. doi: 10.1210/jcemcr/luaf109. eCollection 2025 Jul.
Type 3c diabetes mellitus is a secondary form of diabetes associated with pancreatic disease, primarily chronic pancreatitis, which impairs insulin and glucagon secretion, resulting in inadequate glycemic control. Often misdiagnosed as other types of diabetes, such as type 1 or type 2 diabetes mellitus, type 3c diabetes mellitus is characterized by significant glucose variability, increased insulin requirements, and risk of hypoglycemia. This case report describes a 24-year-old man with a history of hereditary chronic pancreatitis resulting from a serine protease 1 () gene pathogenic variant, who presented with fasting hyperglycemia and elevated glycated hemoglobin requiring early insulin therapy. In the absence of symptoms of exocrine pancreatic insufficiency, specific diagnostic criteria confirmed the diagnosis of pancreatogenic diabetes, and the use of a glucose monitoring system proved essential for optimal management. Therefore, appropriate screening for diabetes in patients with hereditary chronic pancreatitis, combined with accurate diagnosis and close monitoring, can lead to the development of individualized strategies to prevent complications and improve glycemic control.
3c型糖尿病是一种与胰腺疾病相关的继发性糖尿病，主要是慢性胰腺炎，它会损害胰岛素和胰高血糖素的分泌，导致血糖控制不佳。3c型糖尿病常被误诊为其他类型的糖尿病，如1型或2型糖尿病，其特点是血糖显著波动、胰岛素需求增加以及低血糖风险。本病例报告描述了一名24岁男性，有因丝氨酸蛋白酶1（）基因致病性变异导致的遗传性慢性胰腺炎病史，他出现空腹血糖升高和糖化血红蛋白升高，需要早期胰岛素治疗。在没有外分泌性胰腺功能不全症状的情况下，特定的诊断标准确诊为胰腺源性糖尿病，使用葡萄糖监测系统被证明对最佳管理至关重要。因此，对遗传性慢性胰腺炎患者进行适当的糖尿病筛查，结合准确的诊断和密切监测，可制定个性化策略以预防并发症并改善血糖控制。
