Khan Sunaina, Zainab Alishba, Amin Sapna, Iqbal Rashid
Shifa International Hospital Ltd., Pulmonology & Critical Care/SIH, Pakistan.
Current affiliation of Rashid Iqbal: National Skills University, Department of Health Sciences Technology, Pakistan.
J Int Med Res. 2025 May;53(5):3000605251340538. doi: 10.1177/03000605251340538. Epub 2025 May 22.
ObjectiveTo determine the incidence of postoperative pulmonary complications in liver transplantation recipients with abnormal preoperative spirometry.MethodsA retrospective observational study was conducted among 210 patients with abnormal preoperative spirometry who underwent living donor liver transplantation between April 2012 and January 2024. Liver transplantation recipients were divided into two groups based on the spirometry diagnosis of restrictive lung disease or obstructive lung disease. The incidence of postoperative pulmonary complications and impact on patient outcomes were assessed in terms of length of stay in the intensive care unit, total length of stay in the hospital, time on the ventilator, duration of surgery, noninvasive ventilator dependence, reintubation rate, hospital-acquired infection, mortality, and arterial blood gas analysis.ResultsThe incidence of postoperative pulmonary complications was approximately 91.2% in liver transplantation recipients with abnormal preoperative spirometry. The length of stay in the intensive care unit, total length of stay in the hospital, duration of surgery, noninvasive ventilator dependence, reintubation rate, mortality, and hospital-acquired infections did not notably differ between recipients with restrictive lung disease (n = 189) and obstructive lung disease (n = 21).DiscussionAbnormal spirometry resulted in an increased incidence of postoperative pulmonary complications. However, the study suggests that the effects of abnormal spirometry were similar after liver transplantation.ConclusionPreexisting restrictive and obstructive lung diseases are associated with similar risks in liver transplantation recipients. However, as our study had fewer patients with obstructive lung disease, future research should include a comparable number of patients with restrictive and obstructive lung diseases to produce robust data on postoperative complications within this group for liver transplantation.
目的
确定术前肺功能测定异常的肝移植受者术后肺部并发症的发生率。
方法
对2012年4月至2024年1月期间210例术前肺功能测定异常并接受活体肝移植的患者进行回顾性观察研究。根据限制性肺病或阻塞性肺病的肺功能测定诊断将肝移植受者分为两组。从重症监护病房住院时间、住院总时长、机械通气时间、手术时长、无创通气依赖情况、再次插管率、医院获得性感染、死亡率以及动脉血气分析等方面评估术后肺部并发症的发生率及其对患者预后的影响。
结果
术前肺功能测定异常的肝移植受者术后肺部并发症的发生率约为91.2%。限制性肺病患者（n = 189）和阻塞性肺病患者（n = 21）在重症监护病房住院时间、住院总时长、手术时长、无创通气依赖情况、再次插管率、死亡率和医院获得性感染方面无显著差异。
讨论
肺功能测定异常导致术后肺部并发症的发生率增加。然而，该研究表明肝移植后肺功能测定异常的影响相似。
结论
既往存在的限制性和阻塞性肺病在肝移植受者中具有相似的风险。然而，由于我们的研究中阻塞性肺病患者较少，未来的研究应纳入数量相当的限制性和阻塞性肺病患者，以得出关于该组肝移植患者术后并发症的可靠数据。
