妊娠滋养细胞疾病：高级执业护士的临床综述与病例研究报告
Gestational Trophoblastic Disease: A Clinical Review and Case Study Presentation for the Advanced Practice Nurse.
作者信息
Brown Merlendi
机构信息
Merlendi Brown.
出版信息
Clin J Oncol Nurs. 2025 May 19;29(3):E97-E102. doi: 10.1188/25.CJON.E97-E102.
BACKGROUND
Gestational trophoblastic (GT) disease is a continuum of gynecologic disorders that begins with a hydatidiform mole and may progress to GT neoplasia.
OBJECTIVES
The purpose of this article is to review the pathophysiology and clinical manifestations associated with GT disease and provide the advanced practice RN with evidence-based management strategies to use when caring for patients.
METHODS
A case study details a woman aged 42 years with a hydatidiform mole who underwent multiple uterine curettage procedures. The disease progressed to GT neoplasia, characterized by elevated human chorionic gonadotropin (hCG) levels. The patient completed a 10-week course of IV methotrexate, and hCG levels returned to normal range.
FINDINGS
Serial monitoring of hCG levels is paramount when caring for a patient with GT disease. The advanced practice RN should recognize the pathologic significance of rising hCG levels, report these trends to the treating physician, and aim to improve health outcomes.
背景
妊娠滋养细胞疾病是一系列妇科疾病，始于葡萄胎，并可能进展为妊娠滋养细胞肿瘤。
目的
本文旨在综述与妊娠滋养细胞疾病相关的病理生理学和临床表现，并为高级实践注册护士提供在护理患者时使用的循证管理策略。
方法
一项病例研究详细描述了一名42岁患有葡萄胎的女性，她接受了多次刮宫手术。疾病进展为妊娠滋养细胞肿瘤，其特征为人绒毛膜促性腺激素（hCG）水平升高。患者完成了为期10周的静脉注射甲氨蝶呤疗程，hCG水平恢复到正常范围。
研究结果
在护理妊娠滋养细胞疾病患者时，连续监测hCG水平至关重要。高级实践注册护士应认识到hCG水平升高的病理意义，向主治医生报告这些趋势，并致力于改善健康结局。
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