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解读生殖系生物标志物检测中的TP53镶嵌变异:对肿瘤学护士的启示

Deciphering TP53 Mosaic Variants on Germline Biomarker Testing: Implications for Oncology Nurses.

作者信息

Grissom Alyssa, Mahon Suzanne M

机构信息

Alyssa Grissom.

Suzanne M. Mahon.

出版信息

Clin J Oncol Nurs. 2025 May 19;29(3):201-206. doi: 10.1188/25.CJON.201-206.

Abstract

Germline biomarker testing of the TP53 gene can produce confusing results including mosaicism or clonal hematopoiesis of indeterminate potential (CHIP). When noninformative results are reported, additional testing is usually.

摘要

TP53基因的种系生物标志物检测可能会产生令人困惑的结果,包括嵌合体或不确定潜能的克隆性造血(CHIP)。当报告无信息结果时,通常需要进行额外检测。

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本文引用的文献

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Causes of Clonal Hematopoiesis: a Review.
Curr Oncol Rep. 2023 Mar;25(3):211-220. doi: 10.1007/s11912-023-01362-z. Epub 2023 Jan 31.
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Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk.
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