Gencoglu Sule, Yardim Meltem, Akkoc Ramazan Fazil
Department of Dermatology, Gozde Academy Hospital, Malatya, Turkey.
Department of Medical Biochemistry, Yerkoy State Hospital, Yozgat, Turkey.
Dermatol Pract Concept. 2025 Apr 1;15(2):4910. doi: 10.5826/dpc.1502a4910.
Psoriasis may lead to glomerular inflammatory damage and disruption of the podocyte barrier, allowing podocyte degradation products to leak into the urine.
We aimed to analyze the concentrations of podocyte surface glycoprotein podocalyxin (PDX) and podocyte slit protein nephrin in spot urine samples from patients with mild, moderate, or severe psoriasis vulgaris.
A total of 78 participants, including 58 patients diagnosed with mild, moderate, or severe psoriasis vulgaris and 20 healthy controls, were included in the study. Psoriasis was diagnosed based on the typical morphological characteristics of the lesions. Morning urine samples were used to evaluate urine PDX and nephrin levels. Albuminuria was evaluated by calculating the urine albumin-to-creatinine ratio (uACR).
Urinary PDX and nephrin levels were significantly higher in the psoriasis group than in the control group. Urinary PDX and nephrin levels in the mild and moderate psoriasis groups were similar but higher than those in the control group and significantly higher in the severe psoriasis group than in the mild and moderate psoriasis groups. The microalbuminuria rates were similar between the psoriasis and control groups. A significant positive correlation was observed between urine PDX, nephrin, uACR, and SBP. After adjusting for age, BMI, and sex, urine PDX and nephrin levels were found to be independent risk factors for microalbuminuria.
This study showed that podocyte damage in patients with psoriasis begins in the early stages of the disease and significantly increases in the severe stage of the disease.
银屑病可能导致肾小球炎症损伤和足细胞屏障破坏，使足细胞降解产物漏入尿液。
我们旨在分析寻常型轻度、中度或重度银屑病患者随机尿样中足细胞表面糖蛋白足突蛋白（PDX）和足细胞裂孔蛋白nephrin的浓度。
本研究共纳入78名参与者，包括58例诊断为寻常型轻度、中度或重度银屑病的患者和20名健康对照者。根据病变的典型形态特征诊断银屑病。使用晨尿样本评估尿液中PDX和nephrin水平。通过计算尿白蛋白与肌酐比值（uACR）评估蛋白尿。
银屑病组尿中PDX和nephrin水平显著高于对照组。轻度和中度银屑病组尿中PDX和nephrin水平相似，但高于对照组，重度银屑病组显著高于轻度和中度银屑病组。银屑病组和对照组的微量蛋白尿发生率相似。尿PDX、nephrin、uACR和收缩压之间存在显著正相关。在调整年龄、体重指数和性别后，发现尿PDX和nephrin水平是微量蛋白尿的独立危险因素。
本研究表明，银屑病患者的足细胞损伤在疾病早期就已开始，在疾病的重度阶段显著增加。
