Vidal M J, Aguilar E
J Steroid Biochem. 1985 May;22(5):677-9. doi: 10.1016/0022-4731(85)90223-7.
A 25 micrograms dose of testosterone propionate injected at 4 days of age induced 90% anovulation at 100 days of age. The systemic administration of orciprenaline (8 or 16 micrograms) or yohimbine (100 micrograms) did not prevent androgenization. Twenty-five or fifty micrograms of orciprenaline injected intraventricularly reduced only partially (to 54 and 67% respectively) the effectiveness of androgenization. We concluded that beta-adrenergic receptor stimulation had a very limited ability to prevent androgenization, since the beta-stimulation obtained directly with orciprenaline prevented androgenization to a very limited extent, while the possible indirect stimulation through an increase in norepinephrine endogenous release by alpha-2 receptor blocker yohimbine was ineffective.
出生4天时注射25微克丙酸睾酮，在100日龄时可导致90%的动物无排卵。全身性给予奥西那林（8或16微克）或育亨宾（100微克）并不能防止雄激素化。脑室内注射25或50微克奥西那林只能部分降低雄激素化的效果（分别降至54%和67%）。我们得出结论，β-肾上腺素能受体刺激防止雄激素化的能力非常有限，因为直接用奥西那林获得的β-刺激仅在非常有限的程度上防止雄激素化，而通过α-2受体阻滞剂育亨宾增加去甲肾上腺素内源性释放可能产生的间接刺激则无效。
