新生期雄激素化对LEW/Mai大鼠乳腺有丝分裂率以及致癌物诱导的乳腺发育异常和肿瘤发生易感性的影响。
The effects of neonatal androgenization on mammary gland mitotic rate and susceptibility of carcinogen-induced mammary dysplastigenesis and tumorigenesis in LEW/Mai rats.
作者信息
Purnell D M
出版信息
Am J Pathol. 1980 May;99(2):463-74.
The influence of neonatal testosterone propionate treatment (androgenization) on mammary gland mitotic rate (MR) and susceptibility to 7,12-dimethylbenz(alpha)anthracene (DMBA) carcinogenesis was studied in female LEW/Mai rats. Mammary gland MR in androgenized rats was significantly lower than MR in normal rats at all ages studied. Treatment of androgenized rats with DMBA resulted in a significant increase in mammary gland MR in comparison with untreated androgenized rats. MR in DMBA-treated androgenized rats was similar to MR in DMBA-treated normal rats at most intervals after the introduction of the carcinogen. Although mammary epithelial MR in androgenized rats was significantly lower than that of normal rats of comparable age, no evidence of a decrease in susceptibility of mammary epithelium in androgenized rats to DMBA carcinogenesis was found. Instead, androgenized rats had a higher incidence of DMBA-induced mammary dysplasias, with no change in their morphologic or histologic features, than did normal rats; and there was no change in the incidence, latency, or histopathologic appearance of DMBA-induced mammary tumors in androgenized versus normal rats.
在雌性LEW/Mai大鼠中研究了新生期丙酸睾酮处理（雄激素化）对乳腺有丝分裂率（MR）以及对7,12 - 二甲基苯并（α）蒽（DMBA）致癌作用易感性的影响。在所有研究的年龄段，雄激素化大鼠的乳腺MR均显著低于正常大鼠。用DMBA处理雄激素化大鼠后，与未处理的雄激素化大鼠相比，乳腺MR显著增加。在引入致癌物后的大多数时间间隔，经DMBA处理的雄激素化大鼠的MR与经DMBA处理的正常大鼠相似。尽管雄激素化大鼠的乳腺上皮MR显著低于同龄正常大鼠，但未发现雄激素化大鼠的乳腺上皮对DMBA致癌作用的易感性降低。相反，与正常大鼠相比，雄激素化大鼠DMBA诱导的乳腺发育异常发生率更高，但其形态学或组织学特征无变化；并且在雄激素化大鼠与正常大鼠中，DMBA诱导的乳腺肿瘤的发生率、潜伏期或组织病理学表现均无变化。
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