Toussaint Laura, Tram Henriksen Louise, Van Beek Karen, Bolle Stephanie, Demoor-Goldschmidt Charlotte, Gains Jenny, Høyer Morten, Janssens Geert O, Kortmann Rolf-Dieter, Martins Pedro Catia, Timmermann Beate, Scheinemann Katrin, Lassen-Ramshad Yasmin
Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Centre for Paediatric and Adolescent Cancer, Department of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Acta Oncol. 2025 May 22;64:703-707. doi: 10.2340/1651-226X.2025.43028.
The risk of developing neurovascular late effects after radiotherapy is an area of concern when treating pediatric brain tumor patients. However, knowledge is sparse regarding best practice for clinical management during the radiotherapy (RT) planning process and follow-up examinations. This study therefore aimed at mapping how the risk of neurovascular late effects is considered for pediatric brain or skull base tumor patients treated with radiotherapy in Europe.
Two web-based surveys ‑ a RT and a pediatric oncology (PO) survey - were distributed to members of the SIOPE radiotherapy working group or PANCARE and SIOPE brain tumor group, respectively.
The RT survey was completed by 47 participants from 18 different European countries and the PO survey by 33 participants (mostly pediatric (neuro)oncologists) from 15 countries. Overall, the answers highlighted that neurovascular late effects are currently not well included in European clinical practice, neither at the time of radiotherapy nor in the follow-up process.
There is a need for raising general awareness about the topic, as well as for potential risk-stratified prevention measures and follow-up guidelines.
在治疗儿童脑肿瘤患者时，放疗后发生神经血管迟发效应的风险是一个备受关注的领域。然而，关于放疗（RT）计划过程及后续检查期间临床管理的最佳实践，相关知识却很匮乏。因此，本研究旨在梳理欧洲接受放疗的儿童脑或颅底肿瘤患者神经血管迟发效应风险的考量方式。
分别向SIOPE放疗工作组或PANCARE及SIOPE脑肿瘤组的成员发放了两项基于网络的调查问卷——一项放疗调查问卷和一项儿科肿瘤学（PO）调查问卷。
放疗调查问卷由来自18个不同欧洲国家的47名参与者完成，儿科肿瘤学调查问卷由来自15个国家的33名参与者（大多为儿科（神经）肿瘤学家）完成。总体而言，答案表明，目前神经血管迟发效应在欧洲临床实践中未得到充分考量，无论是在放疗时还是在后续过程中。
有必要提高对该主题的普遍认识，以及制定潜在的风险分层预防措施和随访指南。
