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Potential reverse functions of GOLPH3 and GOLPH3L in pyroptotic cell death, with implications in resistance to radiotherapy and chemotherapy.

作者信息

Berkel Caglar

机构信息

Department of Molecular Biology and Genetics, Tokat Gaziosmanpasa University, Tokat, Türkiye.

出版信息

Hum Cell. 2025 May 22;38(4):103. doi: 10.1007/s13577-025-01236-5.

DOI:10.1007/s13577-025-01236-5
PMID:40402191
Abstract
摘要

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1
Potential reverse functions of GOLPH3 and GOLPH3L in pyroptotic cell death, with implications in resistance to radiotherapy and chemotherapy.GOLPH3和GOLPH3L在细胞焦亡性细胞死亡中的潜在反向功能,及其对放疗和化疗耐药性的影响。
Hum Cell. 2025 May 22;38(4):103. doi: 10.1007/s13577-025-01236-5.
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Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.治疗口腔和口咽癌的干预措施:化疗。
Cochrane Database Syst Rev. 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4.
4
Concurrent chemoradiotherapy in non-small cell lung cancer.非小细胞肺癌的同步放化疗
Cochrane Database Syst Rev. 2004 Oct 18(4):CD002140. doi: 10.1002/14651858.CD002140.pub2.
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GOLPH3L antagonizes GOLPH3 to determine Golgi morphology.GOLPH3L 通过拮抗 GOLPH3 来决定高尔基体形态。
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Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma.早期霍奇金淋巴瘤成人患者单纯化疗与化疗联合放疗的比较
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本文引用的文献

1
Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming.靶向GOLPH3L可通过调节STING-NLRP3介导的肿瘤免疫微环境重编程来改善胶质母细胞瘤放疗效果。
Sci Transl Med. 2025 Mar 5;17(788):eado0020. doi: 10.1126/scitranslmed.ado0020.
2
The influence of endothelial metabolic reprogramming on the tumor microenvironment.内皮细胞代谢重编程对肿瘤微环境的影响。
Oncogene. 2025 Jan;44(2):51-63. doi: 10.1038/s41388-024-03228-5. Epub 2024 Nov 20.
3
Inducers and Inhibitors of Pyroptotic Death of Granulosa Cells in Models of Premature Ovarian Insufficiency and Polycystic Ovary Syndrome.
诱导物和抑制剂对卵巢早衰和多囊卵巢综合征模型中颗粒细胞细胞焦亡的影响。
Reprod Sci. 2024 Oct;31(10):2972-2992. doi: 10.1007/s43032-024-01643-3. Epub 2024 Jul 18.
4
The journey of STING: Guiding immune signaling through membrane trafficking.STING 之旅:通过膜转运引导免疫信号转导
Cytokine Growth Factor Rev. 2024 Aug;78:25-36. doi: 10.1016/j.cytogfr.2024.07.003. Epub 2024 Jul 6.
5
Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy.焦亡性细胞死亡:放疗领域新出现的治疗机遇。
Cell Death Discov. 2024 Jan 16;10(1):32. doi: 10.1038/s41420-024-01802-0.
6
Pyroptosis in glioma: Current management and future application.脑胶质瘤中的细胞焦亡:当前的治疗管理与未来的应用
Immunol Rev. 2024 Jan;321(1):152-168. doi: 10.1111/imr.13294. Epub 2023 Dec 8.
7
Metformin antagonizes nickel-refining fumes-induced cell pyroptosis via Nrf2/GOLPH3 pathway in vitro and in vivo.二甲双胍通过 Nrf2/GOLPH3 通路在体外和体内拮抗镍精炼烟尘诱导的细胞焦亡。
Ecotoxicol Environ Saf. 2022 Dec 1;247:114233. doi: 10.1016/j.ecoenv.2022.114233. Epub 2022 Nov 2.
8
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.高尔基磷蛋白 3 通过调控 NLRP3 炎性小体促进胆囊癌细胞的增殖。
Oncol Rep. 2021 Jun;45(6). doi: 10.3892/or.2021.8064. Epub 2021 Apr 28.
9
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?DNA 损伤反应在癌细胞的化疗和放疗抵抗中的作用:DDR 抑制剂能否解决这个问题?
DNA Repair (Amst). 2021 May;101:103074. doi: 10.1016/j.dnarep.2021.103074. Epub 2021 Feb 18.
10
The miR-1185-2-3p-GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1.miR-1185-2-3p-GOLPH3L 通路通过稳定 p53 诱导的丝氨酸蛋白酶抑制剂 E1 促进乳腺癌中的葡萄糖代谢。
J Exp Clin Cancer Res. 2021 Jan 28;40(1):47. doi: 10.1186/s13046-020-01767-9.