Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Department of Cardiology, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran.
DNA Repair (Amst). 2021 May;101:103074. doi: 10.1016/j.dnarep.2021.103074. Epub 2021 Feb 18.
Up to now, many improvements have been made in providing more therapeutic strategies for cancer patients. The lack of susceptibility to common therapies like chemo- and radio-therapy is one of the reasons why we need more methods in the field of cancer therapy. DNA damage response (DDR) is a set of mechanisms which identifies DNA lesions and triggers the repair process for restoring DNA after causing an arrest in the cell cycle. The ability of DDR in maintaining the genome stability and integrity can be favorable to cancerous cells which are exposed to radiation therapy or are treated with chemotherapeutic agents. When DDR mechanisms are error-free in cancer cells, they can escape the expected cellular death and display resistance to treatment. In this regard, targeting different components of DDR can help to increase the susceptibility of advanced tumors to chemo- and radio-therapy.
到目前为止，已经有许多改进方法用于为癌症患者提供更多的治疗策略。对常见疗法（如化疗和放疗）缺乏敏感性是我们需要在癌症治疗领域开发更多方法的原因之一。DNA 损伤反应 (DDR) 是一组机制，可识别 DNA 损伤并触发修复过程，在细胞周期停滞后恢复 DNA。DDR 维持基因组稳定性和完整性的能力有利于暴露于放射治疗或接受化疗药物治疗的癌细胞。当 DDR 机制在癌细胞中无错误时，它们可以逃避预期的细胞死亡并对治疗产生抗性。在这方面，针对 DDR 的不同成分可以帮助提高晚期肿瘤对化疗和放疗的敏感性。
