Cen Shengren, Li Yingpeng, Xiong Xinhao, Ma Zihong, Wang Yongsheng, Gao Xingcheng
Guangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Institute of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230, Guangdong, China.
Discov Oncol. 2025 May 22;16(1):859. doi: 10.1007/s12672-025-02547-7.
Neddylation, as a type of post-translational modification, plays a key role in cancer development. However, the biological characteristics and clinical prognosis value of Neddylation-related genes (NRGs) signatures in clear cell renal cell carcinoma (ccRCC) remain undetermined. Here, we identified two subtypes of NRGs in ccRCC based on TCGA data and constructed a NRGs risk signature (NRGS). Survival analysis, ROC curves, and nomograms showed that NRGS was an important predictor of prognosis in patients with clear cell renal cell carcinoma. We further revealed important correlations between NRGS and clinicopathological features, gene mutations, drug sensitivity, and immune cell infiltration. High NRGS indicates a poorer prognosis for kidney cancer, but higher remission rates with immunotherapy. Drug sensitivity also varies across risk groups. UBB was identified as a hub gene for NRGS and was downregulated in ccRCC, which is associated with poor prognosis. In conclusion, this study provides strategies for predicting prognosis and individualizing treatment for ccRCC.
泛素化修饰作为一种翻译后修饰，在癌症发展中起关键作用。然而，在透明细胞肾细胞癌（ccRCC）中，泛素化相关基因（NRGs）特征的生物学特性和临床预后价值仍未明确。在此，我们基于TCGA数据确定了ccRCC中NRGs的两种亚型，并构建了一个NRGs风险特征（NRGS）。生存分析、ROC曲线和列线图显示，NRGS是透明细胞肾细胞癌患者预后的重要预测指标。我们进一步揭示了NRGS与临床病理特征、基因突变、药物敏感性和免疫细胞浸润之间的重要相关性。高NRGS表明肾癌预后较差，但免疫治疗缓解率较高。不同风险组的药物敏感性也有所不同。UBB被确定为NRGS的一个枢纽基因，在ccRCC中表达下调，这与预后不良有关。总之，本研究为ccRCC的预后预测和个体化治疗提供了策略。
