Yelvington D B, Weiss G K, Ratner A
Physiol Behav. 1985 Mar;34(3):441-3. doi: 10.1016/0031-9384(85)90209-4.
In these experiments, we examined the prolactin (PRL) response during the acquisition of a conditioned avoidance response (CAR). Rats were tested daily in a two-way shuttle box. They were presented with a light stimulation followed by an electric footshock. During each trial period, the rats were given the opportunity to escape the footshock by moving to a safe side of the box. Movement to the appropriate location after the warning signal (light) begins, but before the onset of the footshock, constitutes a CAR. Blood samples were collected from an indwelling cannula and analyzed by radioimmunoassay. PRL levels increased during early acquisition testing, when the rats had not learned to avoid the shock. After one week of testing, acquisition performance increased considerably (70% CARs) while PRL levels remained unchanged. Thus, we were able to show that as rats learned to modify their behavior in response to a stressful situation, they could also modify their PRL response to the stressor.
在这些实验中，我们研究了条件性回避反应（CAR）习得过程中的催乳素（PRL）反应。大鼠每天在双向穿梭箱中接受测试。先对它们进行光刺激，随后施加足部电击。在每个试验阶段，大鼠有机会通过移动到箱子的安全一侧来躲避足部电击。在警告信号（光）开始后但足部电击尚未开始时移动到合适位置，即构成一次条件性回避反应。从留置套管采集血样并通过放射免疫分析法进行分析。在早期习得测试期间，当大鼠尚未学会躲避电击时，PRL水平升高。经过一周的测试，习得表现大幅提高（70%的条件性回避反应），而PRL水平保持不变。因此，我们能够证明，随着大鼠学会根据应激情况改变其行为，它们也能够改变对应激源的PRL反应。
