De Kloet E R, Drago F, Mezey E, Bohus B, De Wied D
Physiol Behav. 1983 Apr;30(4):499-502. doi: 10.1016/0031-9384(83)90211-1.
Three days after stalk section, rats displayed a marked deficit in acquiring a shuttle box avoidance response. The performance of stalk sectioned rats was similar to that of 3-day hypophysectomized rats. At eighteen days after stalk section acquisition of the avoidance response was, however, not different from that of sham-operated controls. Stalk sectioned rats that showed poor performance at three days and that were tested again at eighteen days displayed similar avoidance behavior at eighteen days as their sham-operated controls. The results suggest that pituitary stalk section impairs performance of an active avoidance response. The transient nature of this effect may be due to disruption and subsequent regeneration of vascular contact between pituitary and brain.
垂体柄切断术后三天,大鼠在获得穿梭箱回避反应方面表现出明显缺陷。垂体柄切断的大鼠的表现与三天去垂体大鼠的表现相似。然而,垂体柄切断术后18天,回避反应的获得与假手术对照组并无差异。在三天时表现不佳且在18天时再次接受测试的垂体柄切断大鼠,在18天时表现出与假手术对照组相似的回避行为。结果表明,垂体柄切断会损害主动回避反应的表现。这种效应的短暂性可能是由于垂体与脑之间血管联系的中断及随后的再生。