Mori T, Namiki H, Niki K, Satoh K
Acta Endocrinol (Copenh). 1985 Jun;109(2):208-13. doi: 10.1530/acta.0.1090208.
Changes in circulating prolactin (Prl) levels during and after consecutive administration of bromocriptine-mesilate (CB-154; 0.2 mg/day), a potent suppressor of pituitary Prl secretion, were studied in virgin mice of SHN and BALB/c strains. Plasma Prl levels were lower in CB-154-treated SHN mice than in vehicle-treated controls until the first week of the daily treatment. However, the circulating Prl increased in the experimental mice and surpassed the control levels thereafter. The elevated levels of Prl were maintained throughout the treatment, then they decreased to control levels 1 month after the termination of the treatment. In BALB/c mice given CB-154, the pattern of changes of the circulating Prl levels was almost the same seen in SHN mice; a significant suppression of the Prl levels was observed on the 2nd day of the treatment and the levels increased and reached to the control levels thereafter. The results have demonstrated that in mice the inhibition of pituitary Prl secretion by CB-154 did not persist throughout the period of consecutive administration.
在SHN和BALB/c品系的处女小鼠中，研究了连续给予强效垂体催乳素（Prl）分泌抑制剂甲磺酸溴隐亭（CB - 154；0.2毫克/天）期间及之后循环催乳素（Prl）水平的变化。在每日治疗的第一周之前，CB - 154处理的SHN小鼠的血浆Prl水平低于载体处理的对照小鼠。然而，实验小鼠循环中的Prl随后升高并超过了对照水平。Prl升高的水平在整个治疗过程中维持，然后在治疗终止后1个月降至对照水平。在给予CB - 154的BALB/c小鼠中，循环Prl水平的变化模式与SHN小鼠几乎相同；在治疗的第2天观察到Prl水平有显著抑制，此后水平升高并达到对照水平。结果表明，在小鼠中，CB - 154对垂体Prl分泌的抑制在连续给药期间并未持续。
