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Potential bias in observational PCSK9 inhibitor study.

作者信息

Blais Joseph Edgar, Wong Angel Y S

机构信息

Department of Pharmacology and Pharmacy, Centre for Safe Medication Practice and Research, LKS Faculty of Medicine, The University of Hong Kong, L2-54 Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London  WC1E 7HT, UK.

出版信息

Eur Heart J Cardiovasc Pharmacother. 2025 Aug 12;11(5):483-484. doi: 10.1093/ehjcvp/pvaf041.

DOI:10.1093/ehjcvp/pvaf041
PMID:40403152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12342991/
Abstract
摘要

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本文引用的文献

1
Association of PCSK9 inhibitors with mortality: insights from a retrospective cohort analysis.PCSK9 抑制剂与死亡率的关联:来自回顾性队列分析的见解。
Eur Heart J Cardiovasc Pharmacother. 2024 Oct 4;10(6):505-514. doi: 10.1093/ehjcvp/pvae056.
2
Detecting Selection Bias in Observational Studies-When Interventions Work Too Fast.在观察性研究中检测选择偏倚——当干预起效过快时。
JAMA Intern Med. 2023 Sep 1;183(9):897-898. doi: 10.1001/jamainternmed.2023.2067.
3
Visualizations throughout pharmacoepidemiology study planning, implementation, and reporting.药物流行病学研究规划、实施和报告中的可视化技术。
Pharmacoepidemiol Drug Saf. 2022 Nov;31(11):1140-1152. doi: 10.1002/pds.5529. Epub 2022 Sep 9.
4
Evolocumab's Long-Term Mortality Risk Unclear Due to Shortened Follow-Up of FOURIER.由于 FOURIER 的随访时间缩短,依洛尤单抗的长期死亡率仍不明确。
Am J Cardiovasc Drugs. 2022 Jan;22(1):5-8. doi: 10.1007/s40256-021-00480-y. Epub 2021 May 19.
5
Time-related biases in pharmacoepidemiology.药物流行病学中的时间相关偏倚。
Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1101-1110. doi: 10.1002/pds.5083. Epub 2020 Aug 11.
6
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.依洛尤单抗与急性冠脉综合征后的心血管结局。
N Engl J Med. 2018 Nov 29;379(22):2097-2107. doi: 10.1056/NEJMoa1801174. Epub 2018 Nov 7.
7
Conditioning on future exposure to define study cohorts can induce bias: the case of low-dose acetylsalicylic acid and risk of major bleeding.根据未来暴露情况来定义研究队列可能会导致偏倚:低剂量阿司匹林与大出血风险的案例。
Clin Epidemiol. 2017 Nov 23;9:611-626. doi: 10.2147/CLEP.S147175. eCollection 2017.
8
Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses.指定目标试验可防止观察性分析中出现不朽时间偏倚和其他自伤性偏倚。
J Clin Epidemiol. 2016 Nov;79:70-75. doi: 10.1016/j.jclinepi.2016.04.014. Epub 2016 May 27.
9
Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes.队列研究中的不朽时间偏倚问题:以他汀类药物预防糖尿病进展为例
BMJ. 2010 Mar 12;340:b5087. doi: 10.1136/bmj.b5087.
10
The hazards of hazard ratios.风险比的危害
Epidemiology. 2010 Jan;21(1):13-5. doi: 10.1097/EDE.0b013e3181c1ea43.