Du Lulu, Zhang Liya, Bao Shengzhe, Yan Fangsu, Jiang Wenwei, Wang Hui, Dong Chuanming
Department of Anatomy, Medical College of Nantong University, Nantong 226019, China.
Department of Emergency, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province China.
ACS Biomater Sci Eng. 2025 Jun 9;11(6):3276-3296. doi: 10.1021/acsbiomaterials.5c00615. Epub 2025 May 22.
Spinal cord injury (SCI) is a central nervous system (CNS) disease with a high disability rate, and reconstructing motor function after SCI remains a global challenge. Recent advancements in rehabilitation and regenerative medicine offer new approaches to SCI repair. Electrical stimulation has been shown to alter cell membrane charge distribution, generating action potentials, and affecting cell behavior. This method aids axon regeneration and neurotrophic factor upregulation, crucial for nerve repair. Biomaterials, used as scaffolds or coatings in cell culture and tissue engineering, enhance cell proliferation, migration, differentiation, and tissue regeneration. Electroactive biomaterials combined with electrical stimulation show promise in regenerating nerve, heart, and bone tissues. In this paper, different types of electrical stimulation and biomaterials applied to SCI are described, and the current application and research progress of electrical stimulation combined with biomaterials in the treatment of SCI are described, as well as the future prospects and challenges.
脊髓损伤（SCI）是一种致残率很高的中枢神经系统（CNS）疾病，脊髓损伤后运动功能的重建仍然是一项全球性挑战。康复医学和再生医学的最新进展为脊髓损伤修复提供了新方法。电刺激已被证明可改变细胞膜电荷分布，产生动作电位，并影响细胞行为。该方法有助于轴突再生和神经营养因子上调，这对神经修复至关重要。生物材料在细胞培养和组织工程中用作支架或涂层，可促进细胞增殖、迁移、分化和组织再生。电活性生物材料与电刺激相结合在神经、心脏和骨组织再生方面显示出前景。本文描述了应用于脊髓损伤的不同类型的电刺激和生物材料，阐述了电刺激与生物材料联合应用于脊髓损伤治疗的当前应用情况和研究进展，以及未来前景和挑战。
