Tan Le-Yun, Yang Li, Yu Ming-Tao, Jin Mei-Ling, Lin Xiao-Ping, Chen Yu-Hui, Dong Li, Cai Hui, Chen Xiao-Yang, Huang Shuai, Chen Cheng-Shui, Zhang Fan, Zhang Qing-Ying
Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong 515041, China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
Heart Lung. 2025 Sep-Oct;73:131-138. doi: 10.1016/j.hrtlng.2025.05.007. Epub 2025 May 21.
Exposure to smoking and domestic animals often occur simultaneously. However, epidemiological evidence on the independent and combined effects of smoking and domestic animal exposure on adult lung function is limited.
The purpose of this study was to explore the interaction of smoking and domestic animal exposure on adult lung function.
A total of 6,277 adults were recruited from Southeastern China in this study. Lung function measurements included forced expiratory volume in 1 s (FEV1); forced vital capacity (FVC); FEV1/FVC ratio; peak expiratory flow (PEF); and forced expiratory flow (FEF)25 %, FEF50 %, and FEF75 %. The interaction between smoking and domestic animal exposure was assessed by including a product term in the linear regressions, with the coefficient of the product term (β) used as a measure of interaction. Stratified analysis was conducted for smoking behavior and animal types.
Among smokers, lung function declined more in those with domestic animal exposure than in those without: the βs for FVC, FEV1, FEV1/FVC ratio, and PEF were -0.13 (95 % CI: -0.23, -0.03), -0.15 (-0.23, -0.08), -1.78 (-3.29, -0.27), and -0.43 (-0.67, -0.20), respectively, with them varied with smoking behavior and was greatest on FEV1/FVC ratio. Moreover, we found that only poultry exposure exhibited an interaction with smoking, the βs for FVC; FEV1; FEV1/FVC ratio; PEF; FEF25 %, and FEF50 % were -0.22 (-0.35, -0.08); -0.24 (-0.34, -0.15); -2.93 (-4.86, -1.00); -0.64 (-0.94, -0.35); -0.51 (-0.86, -0.15), and -0.32 (-0.53, -0.11), respectively.
Poultry exposure exacerbated the adverse effects of smoking on lung function in adults. This study suggests that individuals engaged in poultry-related industries should quit smoking to reduce lung function decline.
接触吸烟和家畜的情况经常同时发生。然而，关于吸烟和家畜接触对成人肺功能的独立及联合影响的流行病学证据有限。
本研究旨在探讨吸烟和家畜接触对成人肺功能的相互作用。
本研究共招募了来自中国东南部的6277名成年人。肺功能测量包括第1秒用力呼气量（FEV1）、用力肺活量（FVC）、FEV1/FVC比值、呼气峰值流速（PEF）以及用力呼气流量（FEF）25%、FEF50%和FEF75%。通过在线性回归中纳入一个乘积项来评估吸烟和家畜接触之间的相互作用，将乘积项的系数（β）用作相互作用的度量。对吸烟行为和动物类型进行了分层分析。
在吸烟者中，接触家畜者的肺功能下降幅度大于未接触者：FVC、FEV1、FEV1/FVC比值和PEF的β值分别为-0.13（95%CI：-0.23，-0.03）、-0.15（-0.23，-0.08）、-1.78（-3.29，-0.27）和-0.43（-0.67，-0.20），它们随吸烟行为而变化，且在FEV1/FVC比值上最大。此外，我们发现只有家禽接触与吸烟存在相互作用，FVC、FEV1、FEV1/FVC比值、PEF、FEF25%和FEF50%的β值分别为-0.22（-0.35，-0.08）、-0.24（-0.34，-0.15）、-2.93（-4.86，-1.00）、-0.64（-0.94，-0.35）、-0.51（-0.86，-0.15）和-0.32（-0.53，-0.11）。
家禽接触加剧了吸烟对成人肺功能的不良影响。本研究表明，从事家禽相关行业的个体应戒烟以减少肺功能下降。
