谷胱甘肽代谢与非编码RNA在癌症进展和治疗耐药性中的相互作用。

The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance.

作者信息

Chang Lu, Qin Chao, Wu Jianbo, Jiang Haoqin, Xu Qianqian, Chen Jian, Xu Xiao, Zhang Xinju, Guan Ming, Deng Xuan

机构信息

Department of Laboratory Medicine, Huashan Hospital Fudan University, Shanghai, 200040, China.

出版信息

Redox Biol. 2025 Jul;84:103689. doi: 10.1016/j.redox.2025.103689. Epub 2025 May 19.

DOI:10.1016/j.redox.2025.103689

PMID:40403492

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12150168/

Abstract

Excessive reactive oxygen species (ROS) are closely associated with the initiation and progression of cancers. As the most abundant intracellular antioxidant, glutathione (GSH) plays a critical role in regulating cellular ROS levels, modulating physiological processes, and is intricately linked to tumor progression and drug resistance. However, the underlying mechanisms remain not fully elucidated. Non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are key regulators of GSH levels. Different ncRNAs modulate various pathways involved in GSH metabolism, and these regulatory targets have the potential to serve as therapeutic targets for enhancing cancer treatment. In this review, we summarize the functions of GSH metabolism and highlight the significance of ncRNA-mediated regulation of GSH in cancer progression, drug resistance, and clinical applications.

摘要

过量的活性氧（ROS）与癌症的发生和发展密切相关。作为细胞内最丰富的抗氧化剂，谷胱甘肽（GSH）在调节细胞ROS水平、调节生理过程中起着关键作用，并且与肿瘤进展和耐药性密切相关。然而，其潜在机制仍未完全阐明。非编码RNA（ncRNA），包括长链非编码RNA（lncRNA）和微小RNA（miRNA），是GSH水平的关键调节因子。不同的ncRNA调节参与GSH代谢的各种途径，这些调节靶点有可能作为增强癌症治疗的治疗靶点。在本综述中，我们总结了GSH代谢的功能，并强调了ncRNA介导的GSH调节在癌症进展、耐药性和临床应用中的重要性。