Aragon C M, Amit Z
Alcohol. 1985 Mar-Apr;2(2):357-60. doi: 10.1016/0741-8329(85)90075-8.
The possible existence of a biological marker system mediating voluntary consumption of ethanol in rats has been examined in a series of studies. The working hypothesis underlying this research was that acetaldehyde, the primary metabolite of ethanol, mediates the positive reinforcing properties of ethanol and thus underlies the voluntary consumption of ethanol in both animals and humans. We further hypothesized that brain catalase and aldehyde dehydrogenase, the enzymes controlling the production and elimination of acetaldehyde in the brain, may represent a biological marker system underlying the affinity of the animals to consume ethanol. Data demonstrating that the activity levels of these enzymes are positively correlated with alcohol ingestion seems to suggest that it is likely that the enzyme activity can serve as a predictor of the propensity to drink alcohol. A predictive model is proposed which describes the modulation of voluntary ethanol intake through the activity of these enzymes and their role in determining rates of formation and degradation of acetaldehyde in the brain.
在一系列研究中，对介导大鼠自愿摄入乙醇的生物标志物系统的可能存在情况进行了研究。本研究的基本工作假设是，乙醇的主要代谢产物乙醛介导了乙醇的正强化特性，因此是动物和人类自愿摄入乙醇的基础。我们进一步假设，大脑中的过氧化氢酶和醛脱氢酶，即控制大脑中乙醛产生和消除的酶，可能代表了动物对乙醇摄入亲和力的生物标志物系统。表明这些酶的活性水平与酒精摄入量呈正相关的数据似乎表明，酶活性很可能可以作为饮酒倾向的预测指标。提出了一个预测模型，该模型描述了通过这些酶的活性对自愿乙醇摄入量的调节及其在确定大脑中乙醛生成和降解速率方面的作用。
