Aragon C M, Sternklar G, Amit Z
Alcohol. 1985 Mar-Apr;2(2):353-6. doi: 10.1016/0741-8329(85)90074-6.
The relationship between voluntary ethanol consumption and brain catalase activity was investigated in male Long Evans rats. In the first study, rats which were voluntarily consuming alcohol or water for 25 days were sacrificed by decapitation immediately (group A) or 15 days (group B) following withdrawal of alcohol and their brains analysed for catalase activity. Mean brain catalase activity did not differ among the two groups of rats exposed to ethanol and the ones exposed to water only. Furthermore, there were significant positive correlations between individual voluntary ethanol intake and catalase activity in both groups, (group A:r = .69, p less than or equal to 0.05; group B:r = .54, p less than or equal to 0.05). In the second study, rats were forced to drink high levels of ethanol presented as the only source of fluid for 25 days. Rats were sacrificed and brain, liver, muscle and heart tissue were extracted and analysed for catalase activity. There were no differences in mean brain catalase activity between water and forced ethanol drinking rats indicating that the enzyme was not inducible by high volume ethanol consumption. The results suggest that inherent differences in brain catalase activity may be one of the factors in determining an animal's propensity to voluntarily consume ethanol.
在雄性长 Evans 大鼠中研究了自愿摄入乙醇与脑过氧化氢酶活性之间的关系。在第一项研究中，自愿饮用酒精或水 25 天的大鼠在停止饮酒后立即（A 组）或 15 天后（B 组）断头处死，分析其大脑中的过氧化氢酶活性。暴露于乙醇的两组大鼠与仅暴露于水的大鼠之间，平均脑过氧化氢酶活性没有差异。此外，两组中个体自愿乙醇摄入量与过氧化氢酶活性之间均存在显著正相关（A 组：r = 0.69，p≤0.05；B 组：r = 0.54，p≤0.05）。在第二项研究中，迫使大鼠饮用高浓度乙醇作为唯一的液体来源，持续 25 天。处死大鼠后，提取大脑、肝脏、肌肉和心脏组织并分析过氧化氢酶活性。饮水大鼠和被迫饮用乙醇的大鼠之间，平均脑过氧化氢酶活性没有差异，这表明该酶不会因大量摄入乙醇而被诱导。结果表明，脑过氧化氢酶活性的内在差异可能是决定动物自愿摄入乙醇倾向的因素之一。
