新霉素B的化学修饰

Chemical modification of neamine.

作者信息

Suami T, Nishiyama S, Ishikawa Y, Katsura S

出版信息

Carbohydr Res. 1977 Feb;53(2):239-46. doi: 10.1016/s0008-6215(00)88092-1.

Abstract

The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). Their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains.

摘要

氨基环醇抗生素新霉素已通过从2-脱氧链霉胺部分去除一个或两个羟基进行化学修饰，得到5-脱氧新霉素和6-脱氧新霉素（5和10），以及5,6-二脱氧新霉素（15）。测定了它们对几种微生物的抗菌活性，包括卡那霉素抗性菌株。