新霉素B的化学修饰

Chemical modification of neamine.

作者信息

Suami T, Nishyama S, Ishikawa Y, Katsura S

出版信息

Carbohydr Res. 1978 Aug;65(1):57-64. doi: 10.1016/s0008-6215(00)84212-3.

Abstract

The aminocyclitol antibiotic neamine has been modified by changing the configuration of one or two hydroxyl groups of the aminocyclitol moiety to elucidate the relationship between configuration and antimicrobial activity. 5-Epi-, 6-epi-, and 5,6-diepineamine have been prepared and their antimicrobial activity has been determined against several micro-organisms.

摘要

氨基环醇抗生素新霉素已通过改变氨基环醇部分一个或两个羟基的构型进行修饰，以阐明构型与抗菌活性之间的关系。已制备出5-表新霉素、6-表新霉素和5,6-二表新霉素，并测定了它们对几种微生物的抗菌活性。