Luo Jufeng, Xiang Qiao, Lin Taiping, Liang Rui, Dai Yuzhao, Jiang Tingting, Xu Jianhong, Yue Jirong, Wu Chenkai
Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China.
Osteoarthritis Cartilage. 2025 May 20. doi: 10.1016/j.joca.2025.04.014.
To investigate the associations between total and regional fat-to-muscle mass ratio (FMR) and incident osteoarthritis among adults.
This prospective cohort study included 328,549 participants from the UK Biobank. FMR was calculated as the ratio of fat mass to muscle mass for the whole body, trunk, arms, and legs using a body composition analyzer. Incident osteoarthritis was identified via ICD-10 codes. Cox proportional-hazard regression models were used to identify the association between each type of FMR separately and incident osteoarthritis. Subgroup analyses by age, sex and specific joint sites were conducted.
During a median follow-up of 14.4 years, 48,997 incident osteoarthritis cases were identified. We found an increasing trend in incident osteoarthritis with higher FMRs, particularly among females. In the fully adjusted models, each one standard deviation increase in arm FMR was associated with a 6% higher hazard in males and 11% in females. For leg FMR, the corresponding increases were 5% in males and 14% in females, respectively. Whole-body and trunk FMR were significantly associated with osteoarthritis risk only in women.
FMR was generally positively associated with osteoarthritis risk, with significant associations for arm and leg FMR remaining independent of body mass index across sex and age subgroups. These findings highlight FMR as a valuable marker for identifying those at risk of incident osteoarthritis.
探讨成年人全身及局部脂肪与肌肉质量比（FMR）与骨关节炎发病之间的关联。
这项前瞻性队列研究纳入了来自英国生物银行的328549名参与者。使用身体成分分析仪计算全身、躯干、手臂和腿部的脂肪质量与肌肉质量之比，得出FMR。通过国际疾病分类第10版（ICD - 10）编码确定新发骨关节炎。采用Cox比例风险回归模型分别确定每种FMR与新发骨关节炎之间的关联。并按年龄、性别和特定关节部位进行亚组分析。
在中位随访14.4年期间，共确定了48997例新发骨关节炎病例。我们发现随着FMR升高，骨关节炎发病呈上升趋势，尤其是在女性中。在完全调整模型中，手臂FMR每增加一个标准差，男性发病风险增加6%，女性增加11%。对于腿部FMR，男性和女性相应的增加分别为5%和14%。全身和躯干FMR仅在女性中与骨关节炎风险显著相关。
FMR通常与骨关节炎风险呈正相关，手臂和腿部FMR的显著关联在不同性别和年龄亚组中均独立于体重指数。这些发现突出了FMR作为识别骨关节炎发病风险人群的一个有价值的标志物。
