Mutlu Büşra, Demirci Fatma, Erginer Merve, Duman Şeyma
Department of Metallurgical and Materials Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Yıldırım, 16310, Türkiye.
Central Research Laboratory, Bursa Technical University, Bursa, Yıldırım, 16310, Türkiye.
Macromol Biosci. 2025 Sep;25(9):e00619. doi: 10.1002/mabi.202400619. Epub 2025 May 22.
This study explores the potential of boron-doped baghdadite (BAG) powders incorporated into poly(vinylidene fluoride) (PVDF)-based membrane scaffolds for bone tissue engineering applications. The aim is to enhance the scaffolds' microstructure, surface wettability, thermal behavior, mechanical properties, and biological performance. Composite scaffolds are fabricated by integrating the powders into the PVDF matrix, yielding scaffolds with enhanced material characteristics and functionality. The incorporation of the powders significantly enhances the hydrophilicity of the scaffolds, as evidenced by a notable reduction in contact angle measurements. Mechanical analyses demonstrate that the addition of boron-doped BAG powders reduces the tensile strength and elongation at the break of PVDF scaffolds, attribute to increased pore size, reduced crystallinity, and structural heterogeneity, though the values remain within the range of human cancellous bone. Furthermore, in vitro bioactivity studies reveal the superior apatite-forming ability of the composite scaffolds, indicating their enhanced potential for biomineralization. The results of the cellular adhesion assays indicate an enhanced affinity and proliferation of cells on the membrane scaffolds, which is indicative of improved biocompatibility. In conclusion, the developed PVDF-based membrane scaffolds, reinforce with BAG powders, show promise as effective alternatives to traditional bone graft materials, offering scalable and versatile solutions for regenerative medicine.
本研究探索了掺入聚偏氟乙烯（PVDF）基膜支架中的硼掺杂斜硅钙石（BAG）粉末在骨组织工程应用中的潜力。目的是增强支架的微观结构、表面润湿性、热行为、力学性能和生物学性能。通过将粉末整合到PVDF基质中来制备复合支架，从而获得具有增强材料特性和功能的支架。粉末的掺入显著提高了支架的亲水性，接触角测量值的显著降低证明了这一点。力学分析表明，添加硼掺杂的BAG粉末降低了PVDF支架的拉伸强度和断裂伸长率，这归因于孔径增大、结晶度降低和结构不均匀性，不过这些值仍在人松质骨的范围内。此外，体外生物活性研究揭示了复合支架具有优异的磷灰石形成能力，表明其生物矿化潜力增强。细胞粘附试验结果表明，细胞在膜支架上的亲和力和增殖能力增强，这表明生物相容性得到改善。总之，用BAG粉末增强的新型PVDF基膜支架有望成为传统骨移植材料的有效替代品，为再生医学提供可扩展且通用的解决方案。
