Sugimoto Shu, Kishida Dai, Kobayashi Tatsuya, Tanomogi Naoki, Kurashina Jun-Ichi, Ichikawa Takanori, Shimojima Yasuhiro, Sekijima Yoshiki
Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Clin Rheumatol. 2025 May 22. doi: 10.1007/s10067-025-07501-0.
Takayasu arteritis (TAK) is often associated with other inflammatory diseases. Here, we describe two Japanese patients with TAK complicated by synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Both patients presented with anterior chest pain as their chief complaint and were diagnosed with TAK following SAPHO syndrome. Treatment with glucocorticoids and biological agents led to a rapid improvement in symptoms. A review of the literature identified 11 additional cases of TAK complicated by SAPHO syndrome. SAPHO syndrome frequently precedes TAK, with the diagnostic interval between the two diseases ranging from 1 month to 12 years. No clear association was found between the sites of osteoarticular and vascular involvement. These findings suggest that SAPHO syndrome may be a comorbid condition in patients with TAK. As TAK may develop several years after the diagnosis of SAPHO syndrome, clinicians should consider the possibility of TAK in patients presenting with severe inflammation that cannot be fully explained by SAPHO syndrome alone.
高安动脉炎（TAK）常与其他炎症性疾病相关。在此，我们描述了两名并发滑膜炎、痤疮、脓疱病、骨质增生和骨炎（SAPHO）综合征的日本TAK患者。两名患者均以胸前区疼痛为主诉就诊，在诊断为SAPHO综合征后被诊断为TAK。糖皮质激素和生物制剂治疗使症状迅速改善。文献回顾发现另外11例并发SAPHO综合征的TAK病例。SAPHO综合征常先于TAK出现，两种疾病的诊断间隔为1个月至12年。未发现骨关节和血管受累部位之间存在明确关联。这些发现表明，SAPHO综合征可能是TAK患者的一种合并症。由于TAK可能在SAPHO综合征诊断数年后发生，临床医生应考虑在出现严重炎症且不能仅由SAPHO综合征完全解释的患者中存在TAK的可能性。
