Chen Luxia, Liang Qichang, Chen Sijia, Cheng Hao
Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Dermatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2025 Jul 10;16:1628279. doi: 10.3389/fimmu.2025.1628279. eCollection 2025.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease mainly manifested as skin and osteoarticular lesions. We describe a male patient with SAPHO syndrome who exhibited primary palmoplantar pustulosis (PPP). Notably, his condition worsened during treatment with adalimumab and other immunosuppressants. After switching to ustekinumab, the patient obtained significant improvement in both skin lesions and osteoarticular pain. These findings suggest that ustekinumab may represent an appropriate option for patients with refractory SAPHO syndrome.
滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征是一种罕见的慢性炎症性疾病，主要表现为皮肤和骨关节病变。我们描述了一名患有SAPHO综合征的男性患者，他表现为原发性掌跖脓疱病（PPP）。值得注意的是，在使用阿达木单抗和其他免疫抑制剂治疗期间，他的病情恶化。改用优特克单抗后，患者的皮肤病变和骨关节疼痛均有显著改善。这些发现表明，优特克单抗可能是难治性SAPHO综合征患者的一个合适选择。
