Wang Yiming, Hou Haiyan, Dong Guanzheng, Zhang Hanlin, Zhang Xiaohong, Zhou Yuxia, Xue Mei, Wang Zhihui, Geng Jianxiang, Liu Lisai
Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China.
Virol J. 2025 May 22;22(1):157. doi: 10.1186/s12985-025-02790-y.
Understanding the regional HPV genotype profile is critical for informing targeted vaccination strategies and optimizing cervical cancer screening programs to enhance their effectiveness. This study investigated the prevalence and distribution of human papillomavirus (HPV) genotypes among women with cervical squamous cell carcinoma (CSCC) in Linyi city, China, from 2015 to 2023.
Data were obtained from 606 women histologically diagnosed with CSCC at Linyi Cancer Hospital between January 2015 and December 2023. DNA was extracted from paraffin-embedded tissue samples. HPV genotyping was performed via gene chip-based polymerase chain reaction (PCR) technology. Temporal trends and age-specific variations in HPV genotype distribution were analyzed to provide a comprehensive epidemiological assessment.
The overall prevalence of HPV infection was 94.7% among 606 women with CSCC. HPV 16 was the most prevalent genotype (80.5%), followed by HPV 18 (5.2%), HPV 33 (2.8%), HPV 31 (1.8%), and HPV 58 (1.8%). Single infections were predominant (95.5%), while coinfections were observed in 4.5% of the cases. Age-specific analysis revealed that non-HPV 16 infections were more prevalent in women aged > 45 years, with greater genotype diversity in older age groups. Temporal trends indicated a decline in the prevalence of younger CSCC patients (26-45 years), whereas the prevalence of older women significantly increased.
Our study revealed that HPV genotype diversity in CSCC patients varies with age, highlighting the need for age-stratified and personalized cervical cancer prevention strategies. Enhanced screening efforts for older women are essential because of the greater genotypes diversity in this group. Additionally, the observed trends in HPV prevalence over time suggest that HPV vaccination has effectively reduced the incidence of CSCC in women under 45 years of age. These findings emphasize the importance of expanding vaccination coverage and optimizing screening programs to further reduce the cervical cancer burden across different age groups.
了解区域人乳头瘤病毒（HPV）基因型谱对于制定有针对性的疫苗接种策略以及优化宫颈癌筛查计划以提高其有效性至关重要。本研究调查了2015年至2023年中国临沂市宫颈鳞状细胞癌（CSCC）女性中HPV基因型的流行情况和分布。
数据来自2015年1月至2023年12月期间在临沂市肿瘤医院经组织学诊断为CSCC的606名女性。从石蜡包埋组织样本中提取DNA。通过基于基因芯片的聚合酶链反应（PCR）技术进行HPV基因分型。分析HPV基因型分布的时间趋势和年龄特异性差异，以提供全面的流行病学评估。
606例CSCC女性中HPV感染的总体患病率为94.7%。HPV 16是最常见的基因型（80.5%），其次是HPV 18（5.2%）、HPV 33（2.8%）、HPV 31（1.8%）和HPV 58（1.8%）。单一感染占主导（95.5%），而4.5%的病例观察到合并感染。年龄特异性分析显示，非HPV 16感染在45岁以上女性中更为普遍，老年组的基因型多样性更大。时间趋势表明，年轻CSCC患者（26 - 45岁）的患病率下降，而老年女性的患病率显著增加。
我们的研究表明，CSCC患者的HPV基因型多样性随年龄而异，突出了制定年龄分层和个性化宫颈癌预防策略的必要性。由于该年龄组基因型多样性更大，加强对老年女性的筛查工作至关重要。此外，观察到的HPV流行率随时间变化的趋势表明，HPV疫苗接种有效地降低了45岁以下女性CSCC的发病率。这些发现强调了扩大疫苗接种覆盖范围和优化筛查计划以进一步减轻不同年龄组宫颈癌负担的重要性。
