Luft F C, Sloan R S, Fineberg N S
J Am Coll Nutr. 1985;4(2):233-9. doi: 10.1080/07315724.1985.10720079.
To examine the effect of chloride-containing potassium supplements on chloride titrator estimates of dietary sodium intake, we gave normal subjects diet containing 10, 100, or 200 mEq/d sodium in random order either as such, or supplemented with one of two potassium supplements. One regimen consisted of potassium 45 mEq/d with 12 mEq/d chloride and 33 mEq/d of citrate and gluconate; the other contained 48 mEq/d potassium and 48mEq/d chloride. Increased potassium intake with either supplemented regimen resulted in increased 24-hour potassium excretion, which was manifested in only the diurnal collections. Increased chloride intake resulted in increased urinary chloride excretion both during the day and at night. At all chloride intakes, urinary sodium and chloride excretion were highly correlated. The 48 mEq/d chloride intake generated a relationship with the same slope but with a different intercept from the other two regimens. The highest chloride intake resulted in a greater chloride titrator reading; however, the relationship was sufficiently predictable that adjustments in interpretation could be easily made. We conclude that if daily potassium chloride intake is known, chloride titrators continue to be reliable tools for estimating dietary sodium intake.
为研究含氯钾补充剂对膳食钠摄入量的氯滴定法估计值的影响，我们让正常受试者按随机顺序摄入含10、100或200 mEq/d钠的饮食，饮食要么原样摄入，要么补充两种钾补充剂之一。一种方案是每日摄入45 mEq钾，其中含12 mEq/d氯以及33 mEq/d的柠檬酸盐和葡萄糖酸盐；另一种方案含48 mEq/d钾和48 mEq/d氯。两种补充方案导致的钾摄入量增加均使24小时钾排泄量增加，这仅在日间收集的样本中有所体现。氯摄入量增加导致白天和夜间的尿氯排泄量均增加。在所有氯摄入量水平下，尿钠和尿氯排泄量高度相关。每日摄入48 mEq氯所产生的关系与其他两种方案斜率相同但截距不同。最高氯摄入量导致氯滴定仪读数更高；然而，这种关系具有足够的可预测性，以至于在解读时可轻松进行调整。我们得出结论，如果已知每日氯化钾摄入量，氯滴定仪仍是估计膳食钠摄入量的可靠工具。
