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Macrophage C1q contributes to pulmonary fibrosis by disturbing the metabolism of alveolar epithelial cells.

作者信息

Prüfer Fenja, Steer Beatrix, Kaufmann Eva, Wolf Peter, Adler Barbara, Korfei Martina, Günther Andreas, Königshoff Melanie, Adler Heiko

机构信息

Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany.

University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

出版信息

Clin Transl Med. 2025 May;15(5):e70341. doi: 10.1002/ctm2.70341.

DOI:10.1002/ctm2.70341
PMID:40405488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098955/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/80c3917c88ea/CTM2-15-e70341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/39ebd62122f0/CTM2-15-e70341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/c29e853b7891/CTM2-15-e70341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/80c3917c88ea/CTM2-15-e70341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/39ebd62122f0/CTM2-15-e70341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/c29e853b7891/CTM2-15-e70341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/12098955/80c3917c88ea/CTM2-15-e70341-g002.jpg

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本文引用的文献

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The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis.MTT assay：在批量和单细胞分析中的应用、局限性、陷阱和解释。
Int J Mol Sci. 2021 Nov 26;22(23):12827. doi: 10.3390/ijms222312827.
2
Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death.I型干扰素信号传导介导结核分枝杆菌诱导的巨噬细胞死亡。
J Exp Med. 2021 Feb 1;218(2). doi: 10.1084/jem.20200887.
3
CARD8 inflammasome activation triggers pyroptosis in human T cells.CARD8 炎性小体激活导致人 T 细胞发生细胞焦亡。
EMBO J. 2020 Oct 1;39(19):e105071. doi: 10.15252/embj.2020105071. Epub 2020 Aug 25.
4
Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver.补体 C1q 介导衰老相关炎症性肝中门脉周围肝祖细胞的扩增。
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6717-6725. doi: 10.1073/pnas.1918028117. Epub 2020 Mar 5.
5
Transcriptional regulatory model of fibrosis progression in the human lung.人类肺部纤维化进展的转录调控模型。
JCI Insight. 2019 Nov 14;4(22):131597. doi: 10.1172/jci.insight.131597.
6
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.补体 C1q 激活经典 Wnt 信号通路并促进与衰老相关的表型。
Cell. 2012 Jun 8;149(6):1298-313. doi: 10.1016/j.cell.2012.03.047.
7
Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice.γ-疱疹病毒引起的肺部感染会在Th2偏向型小鼠中诱发进行性肺纤维化。
Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L711-21. doi: 10.1152/ajplung.00007.2005. Epub 2005 Feb 25.
8
Specific inhibition of the classical complement pathway by C1q-binding peptides.C1q结合肽对经典补体途径的特异性抑制作用。
J Immunol. 2001 Dec 15;167(12):7052-9. doi: 10.4049/jimmunol.167.12.7052.