Henry Cyndi, Boucher Magali, Boulay Marie-Ève, Côté Andréanne, Bossé Ynuk
Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval, Québec City, Québec, Canada.
Physiol Rep. 2025 May;13(10):e70387. doi: 10.14814/phy2.70387.
Oscillometry is proposed as a complementary technique to spirometry for methacholine testing. Yet, before being prescribed in conjunction with spirometry, the extent by which the oscillometric readouts are influenced by spirometric maneuvers, especially the deep inspirations, will need to be determined. Herein, 16 very mild-to-mild asthmatics underwent two methacholine challenges on separate visits. On visit 1, the response was tracked by both oscillometry and spirometry, and the challenge was stopped at the provocative concentration causing a decline in forced expiratory volume in 1 s of at least 20%. The same concentration regimen was used on visit 2, but the response was tracked by oscillometry only. The results demonstrated that, except for resistance at 19 Hz, the changes in all oscillometric readouts were greater in the challenge without spirometry (p ≤ 0.02). The maximal change in reactance at 5 Hz (X), for example, was on average 75.8% greater in the challenge without than with spirometry (p = 0.025). The number of doubling concentrations of methacholine that was needed to reach an equivalent change in X was also lower without concomitant spirometry (p = 0.0078). It is concluded that the deep inspirations that are required in spirometry to monitor the response to methacholine decrease the oscillometric response.
振荡法被提议作为用于乙酰甲胆碱测试的肺活量测定法的一种补充技术。然而，在与肺活量测定法联合使用之前，需要确定振荡法读数受肺活量测定操作，尤其是深呼吸影响的程度。在此，16名极轻度至轻度哮喘患者在不同时间接受了两次乙酰甲胆碱激发试验。在第一次就诊时，通过振荡法和肺活量测定法追踪反应，当激发浓度导致1秒用力呼气量至少下降20%时停止激发试验。在第二次就诊时使用相同的浓度方案，但仅通过振荡法追踪反应。结果表明，除了19赫兹时的阻力外，在没有肺活量测定法的激发试验中，所有振荡法读数的变化更大（p≤0.02）。例如，在没有肺活量测定法的激发试验中，5赫兹时电抗（X）的最大变化平均比有肺活量测定法时大75.8%（p = 0.025）。在没有同时进行肺活量测定法的情况下，达到X等效变化所需的乙酰甲胆碱加倍浓度数量也更低（p = 0.0078）。得出的结论是，肺活量测定法中监测对乙酰甲胆碱反应所需的深呼吸会降低振荡法反应。
