Boscia Giacomo, Gnanaraj Ramya, Corradetti Giulia, Soylu Ceren, Kadomoto Shin, Ji Yongsok, Taweebanjongsin Wongsiri, Su Li, Byon Iksoo, Sadda Srinivas R
Doheny Eye Institute, Pasadena, CA, USA.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Curr Eye Res. 2025 Sep;50(9):965-971. doi: 10.1080/02713683.2025.2506524. Epub 2025 May 23.
To compare the computation of the choriocapillaris flow deficit obtained from three different optical coherence tomography angiography devices in healthy subjects.
Twenty-six healthy subjects were included in this post hoc analysis of data from a prospective healthy subject optical coherence tomography angiography study. Fovea-centered 6 × 6 optical coherence tomography angiography volume scans were obtained by all three devices: Heidelberg Spectralis spectral domain optical coherence tomography angiography (Heidelberg, Germany) using a full spectrum probabilistic algorithm (512 × 512 pixels); Zeiss Cirrus 5000 AngioPlex (Zeiss Meditec, Dublin, CA) (spectral domain-optical coherence tomography angiography) using the optical microangiography algorithm (350 × 350 pixels); Zeiss PLEX Elite 9000 swept source optical coherence tomography angiography (Zeiss Meditec, Dublin, CA) using the optical microangiography algorithm (500 × 500 pixels). Choriocapillaris slabs were binarized using Image J (Bethesda, MD) and the choriocapillaris flow deficit % was measured applying a Phansalkar radius of ∼20 µm, adjusted for each device based on the size and resolution of the images.
Twenty-six healthy eyes of 26 subjects with no ocular or systemic disease were included in this analysis. The mean age of the subjects was 47.60 ± 13.00 (range, 26-69) years and 46.15% were females. The choriocapillaris flow deficit % measured by the devices varied significantly from each other ( < .01). The mean choriocapillaris flow deficit % measured by the Spectralis (Heidelberg, Germany) was the highest at 57.00% (±13.21%), followed by the Angioplex at 25.70% (±9.00%), and the Plex Elite at 7.62 (±3.06%). There was a significant positive correlation between choriocapillaris flow deficit % measured by swept source-optical coherence tomography angiography and spectral domain-optical coherence tomography angiography devices (Angioplex and PLEX Elite) using the optical microangiography algorithm ( = 0.78, < .01). Of note, this correlation was better than the correlation between two spectral domain-optical coherence tomography angiography devices using different algorithms (Spectralis, Heidelberg, Germany, full spectrum probabilistic algorithm and Angioplex optical microangiography) ( = 0.389, = .04).
The correlation between swept source and spectral domain optical coherence tomography angiography devices using the same optical coherence tomography angiography algorithm is better than between spectral domain-optical coherence tomography angiography devices using different algorithms.
比较在健康受试者中，通过三种不同的光学相干断层扫描血管造影设备所获得的脉络膜毛细血管血流缺损的计算结果。
本事后分析纳入了26名健康受试者，数据来自一项前瞻性健康受试者光学相干断层扫描血管造影研究。所有三种设备均获取了以黄斑中心凹为中心的6×6光学相干断层扫描血管造影容积扫描图像：德国海德堡的Spectralis光谱域光学相干断层扫描血管造影仪（Heidelberg Spectralis spectral domain optical coherence tomography angiography），采用全光谱概率算法（512×512像素）；美国加利福尼亚州都柏林的蔡司Cirrus 5000 AngioPlex（Zeiss Cirrus 5000 AngioPlex）（光谱域光学相干断层扫描血管造影），采用光学微血管造影算法（350×350像素）；美国加利福尼亚州都柏林的蔡司PLEX Elite 9000扫频源光学相干断层扫描血管造影仪（Zeiss PLEX Elite 9000 swept source optical coherence tomography angiography），采用光学微血管造影算法（500×500像素）。使用Image J（美国马里兰州贝塞斯达）对脉络膜毛细血管层进行二值化处理，并应用约20μm的Phansalkar半径测量脉络膜毛细血管血流缺损百分比，根据各设备图像的大小和分辨率进行调整。
本分析纳入了26名无眼部或全身性疾病受试者的26只健康眼睛。受试者的平均年龄为47.60±13.00（范围26 - 69）岁，女性占46.15%。各设备测量的脉络膜毛细血管血流缺损百分比差异显著（P <.01）。德国海德堡Spectralis测量的平均脉络膜毛细血管血流缺损百分比最高，为57.00%（±13.21%），其次是Angioplex，为25.70%（±9.00%），Plex Elite为7.62（±3.06%）。采用光学微血管造影算法的扫频源光学相干断层扫描血管造影设备与光谱域光学相干断层扫描血管造影设备（Angioplex和PLEX Elite）测量的脉络膜毛细血管血流缺损百分比之间存在显著正相关（r = 0.78，P <.01）。值得注意的是，这种相关性优于使用不同算法的两种光谱域光学相干断层扫描血管造影设备（德国海德堡Spectralis全光谱概率算法和Angioplex光学微血管造影）之间的相关性（r = 0.389，P =.04）。
使用相同光学相干断层扫描血管造影算法的扫频源和光谱域光学相干断层扫描血管造影设备之间的相关性优于使用不同算法的光谱域光学相干断层扫描血管造影设备之间的相关性。
