Department of Orthopedic Surgery, Hallym University Medical College, Chuncheon-Si, Gangwon-Do, Republic of Korea.
Department of Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University Medical College, 77, Sakju-Ro, Chuncheon-Si, Gangwon-Do, 24253, Republic of Korea.
Sci Rep. 2024 Sep 4;14(1):20623. doi: 10.1038/s41598-024-71206-8.
Failure rate after chronic rotator cuff repair is considerably high. Moreover, diabetes mellitus is known as a compromising factor of rotator cuff tear. The effect of Polydeoxyribonucleotide (PDRN) and polynucleotide (PN) on tendon healing and fatty infiltration is unclear as tissue regeneration activator in diabetic state. Therefore, a diabetic rat model with chronic rotator cuff tear was made for mechanical, histologic and blood tests. In the animal study using a diabetic rat cuff repair model, the administration of PDRN and PN increased the load to failure of repaired cuffs and improved tendon healing and decreased fatty infiltration. Also, the plasma levels of vascular endothelial growth factor and fibroblast growth factor were elevated in PDRN and PN administrated groups. We concluded that PDRN and PN appear to boost tendon recovery and reduce the presence of fatty infiltration following cuff repair in diabetic state. Also, PN showed a later onset and a longer duration than PDRN associated with the mean plasma growth factors.
肩袖慢性撕裂修复后的失败率相当高。此外，糖尿病被认为是肩袖撕裂的一个不利因素。多聚脱氧核糖核苷酸（PDRN）和多核苷酸（PN）作为糖尿病状态下的组织再生激活剂，其对肌腱愈合和脂肪浸润的影响尚不清楚。因此，我们制作了一个慢性肩袖撕裂的糖尿病大鼠模型，用于进行力学、组织学和血液测试。在使用糖尿病大鼠肩袖修复模型的动物研究中，PDRN 和 PN 的给药增加了修复肩袖的失效负荷，并改善了肌腱愈合，减少了脂肪浸润。此外，PDRN 和 PN 给药组的血浆血管内皮生长因子和成纤维细胞生长因子水平升高。我们得出结论，PDRN 和 PN 似乎可以促进肌腱恢复，并减少糖尿病状态下肩袖修复后的脂肪浸润。此外，PN 与平均血浆生长因子相关，其起效时间较晚，持续时间较长。
