Augmenting Antioxidant Enzyme-Like Activity and Hydrogen Evolution of MoS@BiS Heterojunction via Ultrasound-Evoked Piezoelectricity for Anti-Inflammation.

Inorganic piezoelectric biomaterials exhibit significant potential for diverse biomedical applications, yet their limited piezoelectric effect has hindered broader utilization. To address this challenge, the study successfully fabricates a heterojunction MoS@BiS with exceptional piezoelectric properties through doping engineering. Comprehensive studies reveal that MoS@BiS efficiently converts mechanical energy into electrical energy, facilitates hydrogen (H) evolution, and enhances the antioxidant enzyme-like performances under ultrasonic irradiation. Moreover, a GSH and GSSG switch cycle is established during the piezocatalytic process, which is conducive to augment the piezoelectricity of MoS@BiS in biological environment. Further investigations demonstrate that deformation of MoS@BiS significantly reduced the free energy required for •OH adsorption, thereby dramatically enhancing its •OH scavenging ability. Both experimental and theoretical results verify a narrowed bandgap of MoS@BiS with or without deformation, indicating that the alteration in bandgap is fundamentally responsible for the enhanced piezoelectric effect, piezocatalytic properties, and H evolution. Capitalizing on the antioxidant capability of H and MoS@BiS itself, the developed MoS@BiS exhibits anti-inflammation activity both in vitro and in vivo, suggesting their potential for the treatment of rheumatoid arthritis and other inflammatory diseases.