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光滑念珠菌引起的肾结石性尿脓毒症:免疫功能正常患者尿脓毒症的罕见病因

Urosepsis From Nephrolithiasis Caused by Candida glabrata: A Rare Etiology of Urinary Sepsis in an Immunocompetent Patient.

作者信息

Van Name Jonathan, Shukla Krunal

机构信息

Internal Medicine, College of Medicine, University of Florida, Gainesville, USA.

出版信息

Cureus. 2025 May 22;17(5):e84600. doi: 10.7759/cureus.84600. eCollection 2025 May.

Abstract

Nephrolithiasis can often serve as an infection nidus, as it is typically associated with urease-producing bacteria and can obstruct the urinary tract, leading to pyelonephritis. While most urinary tract infections from septic stones are bacterial in etiology, fungal causes are less commonly reported in immunocompetent patients and rarely manifest as fungemia. Among fungal causes, is the most common. We describe the case of a 41-year-old immunocompetent patient with a history of recurrent kidney stones and percutaneous nephrostomy tube placement, who developed sepsis from a urinary source secondary to a nephrolithiasis. Blood culture isolates grew . Following identification of the fungus, the patient received a two-week intravenous micafungin course and outpatient stone removal per urological surgery.

摘要

肾结石常可作为感染病灶,因为它通常与产脲酶细菌相关,并且可阻塞尿路,导致肾盂肾炎。虽然大多数由感染性结石引起的尿路感染病因是细菌性的,但在免疫功能正常的患者中,真菌性病因的报道较少,且很少表现为真菌血症。在真菌性病因中, 是最常见的。我们描述了一例41岁免疫功能正常的患者,有复发性肾结石病史且曾行经皮肾造瘘管置入术,该患者因肾结石继发泌尿道感染而发生脓毒症。血培养分离出 。在鉴定出真菌后,患者接受了为期两周的静脉注射米卡芬净治疗,并按照泌尿外科手术安排在门诊进行了结石清除术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/12097844/b5cfcfd1433c/cureus-0017-00000084600-i01.jpg

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