Sui Mingxing, Si Lihui, Chen Zhuoyue, Lu Yingli, Li Hongru
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China.
College of Biological and Agricultural Engineering, Jilin University, Changchun, Jilin, China.
Front Endocrinol (Lausanne). 2025 May 8;16:1577702. doi: 10.3389/fendo.2025.1577702. eCollection 2025.
This review explores the non-invasive applications of Raman spectroscopy in assisted reproductive technology (ART). Raman spectroscopy, a powerful tool for analyzing biological samples, has shown great potential in enhancing ART outcomes through various applications such as sperm quality assessment, oocyte evaluation, and embryo selection. The non-destructive nature and high specificity of this technique enable detailed biochemical analysis at the cellular level, offering valuable insights into cellular processes without harming for the samples. The review highlights recent advancements and studies demonstrating the efficacy of Raman spectroscopy in improving the selection criteria for gametes and embryos, ultimately contributing to higher success rates in ART. Future perspectives on integrating Raman spectroscopy with other technologies to further enhance its applicability in reproductive medicine are also discussed.
本综述探讨了拉曼光谱在辅助生殖技术（ART）中的非侵入性应用。拉曼光谱作为一种分析生物样品的强大工具，通过精子质量评估、卵母细胞评估和胚胎选择等各种应用，在提高ART成功率方面显示出巨大潜力。该技术的无损性质和高特异性能够在细胞水平上进行详细的生化分析，为细胞过程提供有价值的见解，同时不会对样品造成损害。本综述强调了最近的进展和研究，这些进展和研究证明了拉曼光谱在改善配子和胚胎选择标准方面的有效性，最终有助于提高ART的成功率。还讨论了将拉曼光谱与其他技术相结合以进一步提高其在生殖医学中适用性的未来前景。
