Lei Youfeng, Chen Chunyan
Department of Pharmacy, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Front Immunol. 2025 May 8;16:1581885. doi: 10.3389/fimmu.2025.1581885. eCollection 2025.
The application of Traditional Chinese Medicine (TCM) in treating cancer by regulating the immune system has garnered significant attention in the academic community. However, comprehensive quantitative analyses in this field remain limited. This study aims to assess the research progress and key trends over the past decade, providing a framework for future studies.
A comprehensive literature search was conducted on the application of TCM in treating cancer by regulating the immune system from 2015 to 2025 using the Web of Science database. The search terms mainly included cancer, Traditional Chinese Medicine, immunity and so on. Data were analyzed and visualized using Origin, R software, VOSviewer, and CiteSpace.
A total of 2,459 articles were included in the analysis. The number of related publications has steadily increased since 2015. China leads in publication volume and plays a crucial role in international collaboration. The is the leading journal in this field, publishing a substantial number of highly cited studies. Key research areas include keywords such as "apoptosis," "expression," "inflammation," "extract," "," "activation," "antioxidant," and "NF-kappa B," focusing on exploring the role, mechanisms, and efficacy of TCM in modulating immune responses.
Research interest in TCM's role in treating cancer through immune system regulation continues to grow, underscoring its potential in cancer therapy. Current research primarily focuses on the mechanisms by which TCM treats cancer through the modulation of immune cell functions, inhibition of tumor immune evasion, and regulation of immune-related signaling pathways. It also explores its clinical applications and the potential for enhancing the efficacy of immunotherapy.
中医药通过调节免疫系统治疗癌症的应用在学术界备受关注。然而，该领域的综合定量分析仍然有限。本研究旨在评估过去十年的研究进展和关键趋势，为未来研究提供框架。
使用科学网数据库对2015年至2025年中医药通过调节免疫系统治疗癌症的应用进行全面文献检索。检索词主要包括癌症、中医药、免疫等。使用Origin、R软件、VOSviewer和CiteSpace对数据进行分析和可视化。
共纳入2459篇文章进行分析。自2015年以来，相关出版物数量稳步增加。中国在出版物数量上领先，并在国际合作中发挥关键作用。 是该领域的领先期刊，发表了大量被高度引用的研究。关键研究领域包括“凋亡”、“表达”、“炎症”、“提取物”、“ ”、“激活”、“抗氧化剂”和“核因子κB”等关键词，重点探索中医药在调节免疫反应中的作用、机制和疗效。
对中医药通过调节免疫系统治疗癌症作用的研究兴趣持续增长，凸显了其在癌症治疗中的潜力。当前研究主要集中在中医药通过调节免疫细胞功能、抑制肿瘤免疫逃逸和调节免疫相关信号通路治疗癌症的机制上。还探索了其临床应用以及增强免疫治疗疗效的潜力。
