Jiang Yujia, Liang Xiaolan, Sun Hongyi, Yin Ping, Zhou Jing, Yu Chaoqin
Gynecology Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Department of Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Immunol. 2025 May 8;16:1513037. doi: 10.3389/fimmu.2025.1513037. eCollection 2025.
Recent studies have identified that RNA epigenetic modifications, including m6A, m1A, m5C, etc, play pivotal roles in tumor progression. These modifications influence mRNA stability, RNA processing, translational efficiency, and decoding precision. However, comprehensive reviews detailing the connection between m6A RNA modifications and hormone-dependent cancers in both male and female populations remain scarce(breast cancer, ovarian cancer, and endometrial cancer, prostate cancer). In this article, we explore the cellular and molecular roles of various RNA modifications alongside the key elements of the tumor microenvironment. We examine how these RNA modifications influence the development of hormone-dependent cancers through their impact on immune mechanisms. By enhancing our understanding of the function of RNA modifications within the immune systems of four specific tumors, we offer fresh insights for their potential applications in diagnosis and treatment.
最近的研究已经确定，包括m6A、m1A、m5C等在内的RNA表观遗传修饰在肿瘤进展中起着关键作用。这些修饰影响mRNA稳定性、RNA加工、翻译效率和解码精度。然而，详细阐述m6A RNA修饰与男性和女性人群中激素依赖性癌症（乳腺癌、卵巢癌、子宫内膜癌、前列腺癌）之间联系的全面综述仍然很少。在本文中，我们探讨了各种RNA修饰在肿瘤微环境关键要素中的细胞和分子作用。我们研究了这些RNA修饰如何通过对免疫机制的影响来影响激素依赖性癌症的发展。通过加深我们对四种特定肿瘤免疫系统内RNA修饰功能的理解，我们为其在诊断和治疗中的潜在应用提供了新的见解。
