Jia Lili, Shi Kaili, Sun Xiaoyi, Xu Feng, Sun Tao, Gao Chunlin
Department of Pediatrics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Department of Pediatrics, Jinling School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.
Front Pediatr. 2025 May 8;13:1484145. doi: 10.3389/fped.2025.1484145. eCollection 2025.
Mucormycosis is a highly invasive and rare opportunistic infection caused by mucor fungi, characterized by challenging diagnosis and rapid disease progression. It predominantly affects patients with compromised immune systems due to various reasons, such as kidney failure, long-term use of antibiotics or corticosteroids. We recently successfully treated a pediatric patient with rapidly progressive glomerulonephritis accompanied by severe cutaneous mucormycosis. To our knowledge, this is the first reported case of rapidly progressive glomerulonephritis nephritis accompanied by dermatophytosis in a pediatric patient. In this case, we share our management experience, including special nursing experience. Cutaneous mucormycosis progresses quickly and is difficult to diagnose and treat, especially in children with compromised immune function, warranting high vigilance from clinicians and nursing staff. Early diagnosis and targeted treatment are crucial for improving the prognosis of patients. Therefore, once there is a suspicion of a mucormycosis infection, we recommend the early application of various testing methods such as fungal culture, skin biopsy and genetic testing in order to to promptly confirm the diagnosis.
毛霉病是一种由毛霉真菌引起的高度侵袭性且罕见的机会性感染，其特点是诊断具有挑战性且疾病进展迅速。它主要影响因各种原因导致免疫系统受损的患者，如肾衰竭、长期使用抗生素或皮质类固醇。我们最近成功治疗了一名患有快速进展性肾小球肾炎并伴有严重皮肤毛霉病的儿科患者。据我们所知，这是首例报道的儿科患者快速进展性肾小球肾炎伴有皮肤癣菌病的病例。在此病例中，我们分享我们的治疗经验，包括特殊护理经验。皮肤毛霉病进展迅速，难以诊断和治疗，尤其是在免疫功能受损的儿童中，需要临床医生和护理人员高度警惕。早期诊断和针对性治疗对于改善患者预后至关重要。因此，一旦怀疑有毛霉病感染，我们建议尽早应用各种检测方法，如真菌培养、皮肤活检和基因检测，以便及时确诊。
