Reese Elizabeth D, Kane Louisa F, Paquette Catherine E, Frohlich Flavio, Daughters Stacey B
Department of Psychology and Neuroscience, University of North Carolina, 253 Davie Hall, 235 E. Cameron Ave, Chapel Hill, NC, USA.
Curr Addict Rep. 2021 Sep;8(3):440-451. doi: 10.1007/s40429-021-00382-8. Epub 2021 Jul 7.
To provide an overview of the state of translational substance use disorder (SUD) research by evaluating the extent to which psychosocial interventions target neurobiological processes known to contribute to the maintenance of SUD.
A limited number of studies have investigated neurobiological mechanisms of action for commonly utilized SUD treatment approaches. Restrictive samples, post-treatment-only designs, and failure to include substance use outcomes significantly limit the interpretation of these findings.
Much work is needed to bridge the translational gap between neuroscience and psychosocial treatment research for SUD. Despite existing gaps, addiction neuroscience is highly relevant to SUD assessment, case conceptualization, and treatment. Implications are discussed in addition to suggestions for future research.
通过评估心理社会干预针对已知有助于物质使用障碍（SUD）维持的神经生物学过程的程度，概述转化性物质使用障碍研究的现状。
仅有少数研究调查了常用SUD治疗方法的神经生物学作用机制。样本受限、仅采用治疗后设计以及未纳入物质使用结果，这些都显著限制了对这些研究结果的解读。
要弥合神经科学与SUD心理社会治疗研究之间的转化差距，仍有大量工作要做。尽管存在现有差距，但成瘾神经科学与SUD评估、病例概念化及治疗高度相关。除了对未来研究的建议外，还将讨论其影响。
