Lai Shangxiang, Huang Yunshuai, Liu Yumei, Han Fengqing, Zhuang Mu, Cui Xia, Li Zhansheng
State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, No.12 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable, Ministry of Agriculture and Rural Affairs, Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China.
Hortic Res. 2025 Apr 16;12(7):uhaf105. doi: 10.1093/hr/uhaf105. eCollection 2025 Jul.
Clubroot, caused by , poses a serious threat to cruciferous crop production worldwide. Breeding resistant varieties remains the most cost-effective strategy to mitigate yield losses, yet achieving durable, stable, and broad-spectrum resistance continues to be a formidable challenge. Recent advances in genetic and genomic technologies have improved the understanding of complex host-pathogen interactions, leading to the identification of key resistance loci, including dominant resistance genes such as and , as well as quantitative trait loci. This review discusses the genetic mechanisms governing clubroot resistance and highlights applications in breeding, such as marker-assisted selection and CRISPR/-based genome editing, which are accelerating the development of resistant germplasm. Furthermore, integrated management strategies, encompassing resistant cultivars, crop rotation, biocontrol agents, and soil amendments, are emphasized as critical components for sustainable disease management. This review summarizes the major resistance genes against clubroot and discusses potential strategies to address the persistent threat posed by the disease.
由[病原体名称未给出]引起的根肿病对全球十字花科作物生产构成严重威胁。培育抗病品种仍然是减轻产量损失最具成本效益的策略，但实现持久、稳定和广谱抗性仍然是一项艰巨的挑战。遗传和基因组技术的最新进展增进了对复杂宿主-病原体相互作用的理解，从而鉴定出关键抗性位点，包括显性抗性基因如[基因名称未给出]和[基因名称未给出]，以及数量性状位点。本综述讨论了控制根肿病抗性的遗传机制，并强调了其在育种中的应用，如标记辅助选择和基于CRISPR/[技术名称未给出]的基因组编辑，这些正在加速抗病种质的开发。此外，综合管理策略，包括抗病品种、轮作、生物防治剂和土壤改良，被强调为可持续病害管理的关键组成部分。本综述总结了抗根肿病的主要抗性基因，并讨论了应对该病害持续威胁的潜在策略。
