Al-Gburi Hashim Hamood Jabbar, Hassanzadeh-Tabrizi Sayed Ali, Jabbarzare Saeid
Institute of Manufacturing Engineering and Industrial Technologies, Na.C, Islamic Azad University, Najafabad, Iran.
Int J Biomater. 2025 May 15;2025:7290633. doi: 10.1155/ijbm/7290633. eCollection 2025.
Cancer is a pervasive and devastating disease affecting various parts of the body, posing significant challenges to human societies. Recently, the development of novel magnetic and biocompatible nanoparticles has emerged as a promising approach for magnetic hyperthermia in cancer treatment, complementing existing therapeutic methods. In the present work, CuZnFeO mixed spinel nanoparticles were produced via a sol-gel combustion route. The produced magnetic nanopowders were studied via FTIR, SEM, XRD, and VSM techniques. XRD results confirmed the formation of the spinel structure of ferrites. Microstructural investigations showed that the synthesized nanoparticles have a particle size ranging from 20 to 200 nm. The VSM results displayed that the saturation magnetization and coercivity of CuZnFeO nanoparticles were 57 emu/g and 24 Oe, respectively. Saturation magnetization for the CuZnFeO specimens improved with increasing heat treatment temperature. In order to examine the samples' heating effectiveness for magnetic hyperthermia therapy, various magnetic fields were used. The temperature of the CuZnFeO powders increased from 37°C to 47°C in 10 min when exposed to a 400-Oe magnetic field and 200-kHz frequency. Results showed that the fabricated products have the potential to be used as hyperthermia agents for cancer therapy. The novelty of this study focuses on the use of CuZnFeO mixed spinel as a new hyperthermia agent with more biocompatible constituent elements.
癌症是一种影响身体各个部位的普遍且具有毁灭性的疾病，给人类社会带来了重大挑战。最近，新型磁性和生物相容性纳米颗粒的开发已成为癌症治疗中磁热疗的一种有前景的方法，对现有治疗方法起到补充作用。在本工作中，通过溶胶 - 凝胶燃烧法制备了CuZnFeO混合尖晶石纳米颗粒。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、X射线衍射（XRD）和振动样品磁强计（VSM）技术对所制备的磁性纳米粉末进行了研究。XRD结果证实了铁氧体尖晶石结构的形成。微观结构研究表明，合成的纳米颗粒粒径范围为20至200纳米。VSM结果显示，CuZnFeO纳米颗粒的饱和磁化强度和矫顽力分别为57 emu/g和24 Oe。CuZnFeO样品的饱和磁化强度随热处理温度的升高而提高。为了检验样品在磁热疗中的加热效果，使用了各种磁场。当暴露于400 Oe磁场和200 kHz频率时，CuZnFeO粉末的温度在10分钟内从37°C升高到47°C。结果表明，所制备的产品有潜力用作癌症治疗的热疗剂。本研究的新颖之处在于使用CuZnFeO混合尖晶石作为一种具有更多生物相容性组成元素的新型热疗剂。
