单剂量静脉注射吡仑帕奈用于术后早期癫痫预防的首例病例。
The First Case of a Single-Dose, Intravenous Perampanel Administration for Early Postoperative Seizure Prophylaxis.
作者信息
Sugii Narushi, Yamada Takeshi, Ishikawa Eiichi
机构信息
Department of Neurosurgery Institute of Medicine, University of Tsukuba Tsukuba Japan.
Tsukuba Clinical Research and Development Organization University of Tsukuba Tsukuba Japan.
出版信息
Clin Case Rep. 2025 May 22;13(5):e70455. doi: 10.1002/ccr3.70455. eCollection 2025 May.
Abstract
Early postoperative epileptic seizure (EPS) may occur in neurosurgical patients. Perampanel has an extended serum half-life plus a rapid onset of action. The intravenous form of perampanel was first launched in Japan, and it may be an option for EPS prevention in brain surgery.
摘要
神经外科患者术后早期可能发生癫痫发作（EPS）。吡仑帕奈具有较长的血清半衰期且起效迅速。吡仑帕奈静脉制剂首先在日本上市，它可能是预防脑外科手术中EPS的一种选择。
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