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单剂量静脉注射吡仑帕奈用于术后早期癫痫预防的首例病例。

The First Case of a Single-Dose, Intravenous Perampanel Administration for Early Postoperative Seizure Prophylaxis.

作者信息

Sugii Narushi, Yamada Takeshi, Ishikawa Eiichi

机构信息

Department of Neurosurgery Institute of Medicine, University of Tsukuba Tsukuba Japan.

Tsukuba Clinical Research and Development Organization University of Tsukuba Tsukuba Japan.

出版信息

Clin Case Rep. 2025 May 22;13(5):e70455. doi: 10.1002/ccr3.70455. eCollection 2025 May.

DOI:10.1002/ccr3.70455
PMID:40406550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12096365/
Abstract

Early postoperative epileptic seizure (EPS) may occur in neurosurgical patients. Perampanel has an extended serum half-life plus a rapid onset of action. The intravenous form of perampanel was first launched in Japan, and it may be an option for EPS prevention in brain surgery.

摘要

神经外科患者术后早期可能发生癫痫发作（EPS）。吡仑帕奈具有较长的血清半衰期且起效迅速。吡仑帕奈静脉制剂首先在日本上市，它可能是预防脑外科手术中EPS的一种选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/f84859a349da/CCR3-13-e70455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/d5e61d29f0e8/CCR3-13-e70455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/5df9015d69eb/CCR3-13-e70455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/f84859a349da/CCR3-13-e70455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/d5e61d29f0e8/CCR3-13-e70455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/5df9015d69eb/CCR3-13-e70455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5a0/12096365/f84859a349da/CCR3-13-e70455-g003.jpg

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本文引用的文献

1
Early Postoperative Seizures Following Awake Craniotomy and Functional Brain Mapping for Lesionectomy.清醒开颅术和功能脑图切除病变术后早期发作
World Neurosurg. 2024 Jan;181:e732-e742. doi: 10.1016/j.wneu.2023.10.119. Epub 2023 Oct 28.
2
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy.静脉用吡仑帕奈作为日本癫痫患者口服制剂的替代选择。
Epilepsia Open. 2023 Dec;8(4):1369-1382. doi: 10.1002/epi4.12804. Epub 2023 Aug 30.
3
Predictive factors for post operative seizures following meningioma resection in patients without preoperative seizures: a multicenter retrospective analysis.
术前无癫痫发作的脑膜瘤切除术后癫痫发作的预测因素：一项多中心回顾性分析
Acta Neurochir (Wien). 2023 May;165(5):1333-1343. doi: 10.1007/s00701-023-05571-0. Epub 2023 Mar 28.
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Factors associated with preoperative and early and late postoperative seizures in patients with supratentorial meningiomas.与幕上脑膜瘤患者术前、早期和晚期术后癫痫发作相关的因素。
Epileptic Disord. 2023 Apr;25(2):244-254. doi: 10.1002/epd2.20021. Epub 2023 May 6.
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Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review.吡仑帕奈用于脑肿瘤相关性癫痫：一项系统评价。
Brain Sci. 2023 Feb 14;13(2):326. doi: 10.3390/brainsci13020326.
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Levetiracetam Versus Levetiracetam Plus Sodium Channel Blockers for Postoperative Epileptic Seizure Prevention in Brain Tumor Patients.左乙拉西坦与左乙拉西坦加钠通道阻滞剂用于预防脑肿瘤患者术后癫痫发作的比较
Cureus. 2022 May 10;14(5):e24894. doi: 10.7759/cureus.24894. eCollection 2022 May.
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Preoperative antiepileptic drug prophylaxis for early postoperative seizures in supratentorial meningioma: a single-center experience.幕上脑膜瘤术后早期癫痫发作的术前抗癫痫药物预防：单中心经验。
J Neurooncol. 2022 May;158(1):59-67. doi: 10.1007/s11060-022-04009-4. Epub 2022 Apr 17.
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Predictors of early postoperative epileptic seizures after awake surgery in supratentorial diffuse gliomas.幕上弥漫性胶质瘤清醒手术术后早期癫痫发作的预测因素。
J Neurosurg. 2020 Mar 13;134(3):683-692. doi: 10.3171/2020.1.JNS192774. Print 2021 Mar 1.
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Glutamatergic synaptic input to glioma cells drives brain tumour progression.谷氨酸能突触输入到神经胶质细胞瘤驱动脑肿瘤的进展。
Nature. 2019 Sep;573(7775):532-538. doi: 10.1038/s41586-019-1564-x. Epub 2019 Sep 18.
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J Neurooncol. 2019 May;142(3):577-586. doi: 10.1007/s11060-019-03131-0. Epub 2019 Feb 25.