Andreoli María F, De Francesco Pablo N, Titova Olga E, Perello Mario, Schiöth Helgi B
Instituto de Desarrollo e Investigaciones Pediátricas (IDIP), Children's Hospital HIAEP "Sor María Ludovica" La Plata - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Buenos Aires, Argentina.
CONICET, La Plata, Buenos Aires, Argentina.
Diabetes Obes Metab. 2025 Aug;27(8):4427-4435. doi: 10.1111/dom.16483. Epub 2025 May 23.
While LEAP2 is increasingly recognized as an appetite-regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended-energy breakfast, exploring potential association with voluntary energy intake and modulation by weight status and (2) to examine the interplay between postprandial LEAP2 and insulin concentrations.
Eighty-four men with normal weight (NW) and 48 with overweight or obesity (OW/OB) received a test meal; pre- and postprandial LEAP2 and insulin concentrations were assessed. Energy intake was calculated by multiplying the weight of the food items consumed by their energy content according to their label.
Fasting LEAP2 was positively associated with glycaemia in participants with NW [Beta (95% CI): 0.289 (0.058, 0.520), p = 0.015] but not with OW/OB. Sixty-seven participants consumed the entire test meal (CMC, complete meal consumption); the rest consumed only part (PMC, partial meal consumption). Postprandial LEAP2 concentration was higher in the PMC (p = 0.017) than in the CMC group and in participants with OW/OB (p = 0.046). Pre (p = 0.027) and postprandial (p = 0.031) LEAP2 was inversely related to ingested calories, but only in PMC and independent of weight status. Postprandial insulin increase (p < 0.001) depended on LEAP2 only in CMC (p = 0.017) and was independent of weight status.
The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status.
虽然LEAP2越来越被认为是一种调节食欲的激素，但其在进餐调节中的作用以及餐后LEAP2浓度的动态变化在人类中仍知之甚少。本研究的目的是：（1）评估推荐能量早餐后的餐后LEAP2浓度，探索其与自愿能量摄入的潜在关联以及体重状态对其的调节作用；（2）研究餐后LEAP2与胰岛素浓度之间的相互作用。
84名体重正常（NW）的男性和48名超重或肥胖（OW/OB）的男性接受了一顿测试餐；评估了餐前和餐后的LEAP2和胰岛素浓度。能量摄入量通过将所食用食物的重量乘以其标签上的能量含量来计算。
NW参与者的空腹LEAP2与血糖呈正相关[β（95%可信区间）：0.289（0.058，0.520），p = 0.015]，但OW/OB参与者则不然。67名参与者食用了整份测试餐（CMC，完整进餐）；其余参与者只食用了部分（PMC，部分进餐）。PMC组的餐后LEAP2浓度高于CMC组（p = 0.017），且在OW/OB参与者中也更高（p = 0.046）。餐前（p = 0.027）和餐后（p = 0.031）LEAP2与摄入的卡路里呈负相关，但仅在PMC组中如此，且与体重状态无关。餐后胰岛素升高（p < 0.001）仅在CMC组中依赖于LEAP2（p = 0.017），且与体重状态无关。
LEAP2与能量摄入和餐后胰岛素升高的关系受进餐量影响，但不受体重状态影响。
