Cohen Ann D, Villemagne Victor L
Department of Psychiatry, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alzheimers Dement. 2025 May;21(5):e70291. doi: 10.1002/alz.70291.
β-Amyloid (Αβ) imaging revolutionized the in vivo assessment of Alzheimer's disease (AD) Αβ pathology and its changes over time, increasing our insights into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional and global Aβ burden in the brain, proving essential for the differential diagnosis, staging, and evaluation of disease-specific anti-Αβ therapeutic approaches. Longitudinal observations, coupled with different disease-specific biomarkers to assess potential downstream effects of Aβ, have confirmed that Αβ deposition in the brain starts decades before the onset of symptoms. Aβ imaging studies continue to refine our understanding of the role of Αβ deposition in AD, and its relation to other imaging and fluid biomarkers. HIGHLIGHTS: Αβ imaging revolutionized the in vivo assessment of Alzheimer's disease Αβ pathology. Αβ imaging has increased our insights into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional and global Αβ burden in the brain. Αβ imaging is essential for the differential diagnosis, staging, and evaluation of disease-specific anti-Αβ therapeutic approaches. Αβ imaging studies continue to refine our understanding of the role of Αβ deposition in Alzheimer's disease, and its relation to other imaging and fluid biomarkers.
β-淀粉样蛋白（Aβ）成像彻底改变了阿尔茨海默病（AD）Aβ病理的体内评估及其随时间的变化，通过提供大脑区域和整体Aβ负担的高度准确、可靠且可重复的定量数据，增加了我们对大脑中Aβ沉积的认识，这对疾病特异性抗Aβ治疗方法的鉴别诊断、分期和评估至关重要。纵向观察，结合不同的疾病特异性生物标志物来评估Aβ的潜在下游效应，证实大脑中的Aβ沉积在症状出现前数十年就已开始。Aβ成像研究不断完善我们对Aβ沉积在AD中的作用及其与其他成像和体液生物标志物关系的理解。
Aβ成像彻底改变了阿尔茨海默病Aβ病理的体内评估。Aβ成像通过提供大脑区域和整体Aβ负担的高度准确、可靠且可重复的定量数据，增加了我们对大脑中Aβ沉积的认识。Aβ成像对疾病特异性抗Aβ治疗方法的鉴别诊断、分期和评估至关重要。Aβ成像研究不断完善我们对Aβ沉积在阿尔茨海默病中的作用及其与其他成像和体液生物标志物关系的理解。
