Davion Jean-Baptiste, Tard Céline, Viard Romain, Fragoso Loren, Wilu-Wilu Amina, Defebvre Luc, Kuchcinski Grégory, Delbeuck Xavier
U1172 - LilNCog - Lille Neuroscience & Cognition, Univ. Lille, Inserm, CHU Lille, Lille, France.
Department of Neurology, CHU Lille, Lille, France.
Eur J Neurol. 2025 May;32(5):e70216. doi: 10.1111/ene.70216.
Theory of Mind (ToM) Refers to the ability to infer other people's thoughts (Cognitive ToM) and emotions (Affective ToM). Myotonic Dystrophy Type 1 (DM1) Patients Showed an impairment of ToM capacities, but the underlying neural mechanisms remain poorly understood.
We included 58 adult non-congenital DM1 patients from the DMVASCOG cohort, who underwent a ToM evaluation using the Movie for the Assessment of Social Cognition and a brain MRI. Association of ToM scores with cortical thickness and gyrification was assessed using FreeSurfer software, and associations with white matter hyperintensities were assessed using SVR-LSM. Finally, we included all the significantly associated parameters in a multivariate model.
The ToM total score and cognitive subscore were both associated with the local gyrification in the right superior parietal gyrus and with the hyperintensities in the bilateral temporopolar white matter. The ToM total score was also associated with hyperintensities in the bilateral temporo-parietal and left frontal white matter. Multivariate models based on these parameters allowed a better prediction of the ToM total score (R = 0.49) and cognitive subscore (R = 0.52) than univariate models. There was no association between ToM measures and cortical thickness, nor between brain MRI measures and affective subscore/error types.
The ToM cognitive involvement in DM1 is associated with both the gyrification in the right superior parietal gyrus and the volume of hyperintensities in the anterior-temporal white matter, suggesting the possible joint implication of a neurodevelopmental phenomenon and disconnections arising from white matter changes.
心理理论（ToM）是指推断他人思想（认知ToM）和情感（情感ToM）的能力。1型强直性肌营养不良（DM1）患者表现出心理理论能力受损，但其潜在的神经机制仍知之甚少。
我们纳入了来自DMVASCOG队列的58名成年非先天性DM1患者，他们使用社会认知评估电影进行了心理理论评估，并接受了脑部MRI检查。使用FreeSurfer软件评估心理理论分数与皮质厚度和脑回化的相关性，使用SVR-LSM评估与白质高信号的相关性。最后，我们将所有显著相关参数纳入多变量模型。
心理理论总分和认知子分数均与右侧顶上回的局部脑回化以及双侧颞极白质的高信号相关。心理理论总分还与双侧颞顶叶和左侧额叶白质的高信号相关。基于这些参数的多变量模型比单变量模型能更好地预测心理理论总分（R = 0.49）和认知子分数（R = 0.52）。心理理论测量与皮质厚度之间、脑部MRI测量与情感子分数/错误类型之间均无关联。
DM1中心理理论的认知参与与右侧顶上回的脑回化以及颞前白质高信号的体积均相关，提示神经发育现象和白质变化引起的连接中断可能共同起作用。
